Causes of death among 91 HIV-infected adults in the era of potent antiretroviral therapy

La Presse médicale
Mustapha SodqiKamal Marhoum El Filali

Abstract

To describe the causes of death occurring during the antiretroviral therapy in Casablanca. Retrospective study of a cohort of HIV positive patients attending the infectious diseases unit of Casablanca receiving antiretroviral therapy. Files of 91 patients who died were analyzed. Since June 1999, 1243 patients were treated and 91 deaths occurred (7, 3%). The mean age at time of death was 36 years. Forty-six patients were male (50, 5%) and 86 were stage C (94, 5%). At the initiation of treatment, mean CD4 count was 96 cells/mL (1-626) and mean plasma HIV- RNA was 5, 65 log10. They have received antiretroviral therapy for a mean of 9 months (1-48 months). At time of death, 37 patients (52, 8%) had a CD4 count greater than 200 cells/mL and 16 patients (23%) had undetectable plasma viral load. In 57 cases (63%), the death occurred within the first year after start of antiretroviral therapy. The main causes of death were: tuberculosis (35%), cryptosporidiosis (19%), cryptococcosis (13%), cerebral toxoplasmosis (9%), Kaposi sarcoma (6%), non Hodgkin's lymphoma (2%), atypical mycobacteriosis (2%), cerebral lymphoma (1%), aspergillosis (1%), HIV wasting syndrome (1%) and cancer of cervix (1%). Non AIDS related deaths were noticed in thr...Continue Reading

References

Apr 24, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H ValdezM M Lederman
Sep 20, 2006·Annals of Internal Medicine·Judith E SackoffLucia V Torian
Aug 21, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Elena LosinaYitades Gebre
Jan 8, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Samuel A BozzetteThomas A Louis
Nov 18, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Peter MacPhersonPaul Pronyk
Apr 13, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·UNKNOWN Antiretroviral Therapy Cohort Collaboration
Apr 29, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Yi-Chien LeeYee-Chun Chen

❮ Previous
Next ❯

Citations

Oct 31, 2015·Journal de mycologie médicale·M El FaneK Marhoum El Filali
Aug 12, 2016·Infectious Agents and Cancer·Wafaa Mohamed HusseinMeriem Khyatti

❮ Previous
Next ❯

Related Concepts

Related Feeds

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.

AIDS Malignancies (ASM)

HIV infection increases the risk of non-communicable diseases common in the aged, including cardiovascular disease, neurocognitive decline, non-aids malignancies, osteoporosis, and frailty. Discover the latest research in AIDS malignancies.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.