Causes of death among persons with multiple sclerosis

Multiple Sclerosis and Related Disorders
Gary CutterRuth Ann Marrie

Abstract

Multiple Sclerosis (MS) is a leading cause of disability among young Americans. Reports suggest that life expectancy (i.e., average age at death) remains reduced as compared to the general population, but underlying causes of death (UCOD) are less well-characterized. To describe the cause-specific mortality among participants enrolled in the North American Research Committee on Multiple Sclerosis (NARCOMS) registry and to compare the profile of these causes by age, sex, race and disability status at entry into NARCOMS, with U.S. mortality data. The underlying cause of death (UCOD), any mention cause of death and proportionate mortality were compared among U.S. NARCOMS participants by age, sex, race and disability status. Of the 32,445 participants to be considered for this study, 2,927 had died. Compared to survivors, decedents were older at enrollment and MS diagnosis, more likely to be male, and had less education. UCOD differed markedly by age group. In both sexes, MS as the UCOD was proportionately lower by 20% or more in those aged 25-39 compared to those aged 75 or older. Cancer and cardiovascular causes were more frequent as causes of death with increasing age, but were less than expected at older ages. The effect of dis...Continue Reading

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Citations

Sep 7, 2016·Expert Opinion on Pharmacotherapy·Nikolaos GrigoriadisGünther F L Hofbauer
Feb 21, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Shaik Ahmed SanaiBianca Weinstock-Guttman
Jul 8, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Gary R CutterRuth Ann Marrie
Jul 21, 2017·Journal of Medical Economics·Melissa A FrascoNina Thomas
Jul 6, 2018·Acta neurologica Belgica·Musa MuhtarogluMehtap Malkoc
Apr 11, 2019·Therapeutic Advances in Neurological Disorders·Luisa KlotzHeinz Wiendl
Mar 1, 2017·International Journal of MS Care·Scott D NewsomeDavid E Jones
Jul 9, 2021·Multiple Sclerosis and Related Disorders·Michela TinelliPer Soelberg Sørensen
May 21, 2021·Neurology·Ruth Ann MarriePatti Groome
Aug 10, 2021·Multiple Sclerosis and Related Disorders·Fettah ErenAysegul Demir
Sep 17, 2021·Neurology·Ruth Ann MarriePatti Groome

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