PMID: 6537916Jan 1, 1984Paper

Causes of death in febrile granulocytopenic cancer patients receiving empiric antibiotic therapy

European Journal of Cancer & Clinical Oncology
J P SculierJ Klastersky

Abstract

We reviewed the causes of death of 55 granulocytopenic patients who received empiric antibiotic treatment for fever according to an EORTC cooperative protocol; 53 presented cancer and 2 aplastic anemia. Among the 55 patients, 19 (35%) deaths were attributed to infection: 16 to bacterial and 3 to fungal infections. Among the patients with bacterial infections, 12 died from septic shock, 3 from pneumonia and 1 from Pseudomonas aeruginosa meningitis. The most frequent non-infectious causes of death were the cancer progression (18%) and hemorrhagic complications (27%), most often cerebromeningeal in relationship to thrombocytopenia. A large number of the patients who died from infection (78%) and hemorrhage (74%) had advanced cancer with poor chances to respond to anticancer therapy.

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Citations

Mar 1, 1995·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·J P Sculier
May 1, 1996·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·C Rossi, J Klastersky
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May 1, 1997·Antimicrobial Agents and Chemotherapy·A El-YazigiF J Baillie
Apr 1, 1991·Baillière's Clinical Haematology·C ViscoliD Rogers

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