Causes of death in Japanese patients with atrial fibrillation: The Fushimi Atrial Fibrillation Registry

European Heart Journal. Quality of Care & Clinical Outcomes
Yoshimori AnMasaharu Akao

Abstract

To investigate the causes of death and the associated clinical factors in patients with atrial fibrillation (AF) in the contemporary clinical practice. The Fushimi AF Registry is a community-based prospective survey of AF patients since March 2011 in Fushimi-ku, Kyoto. We investigated causes of death and the clinical indicators of cardiovascular (CV) and non-CV death in 4045 patients with available follow-up data by the end of November 2016. The mean age was 73.6 ± 10.9 years and the mean CHA2DS2-VASc score was 3.38 ± 1.69. Oral anticoagulants were prescribed in 55% of patients. During a median follow-up of 1105 days, there were 705 all-cause deaths (5.5%/year); 180 CV (26% of total deaths), 381 non-CV (54%), and 144 undetermined causes (20%). The most common causes of CV and non-CV death were heart failure (14.5%), malignancy (23.1%), and infection/sepsis (17.3%), while mortality due to stroke was only 6.5%. Mortality due to infection/sepsis and undetermined causes increased with aging. On multivariate analysis, the strongest indicator of CV death was pre-existing heart failure [hazard ratio (HR) 2.42, 95% confidence interval (CI) 1.66-3.54; P < 0.001] and that of non-CV death was anaemia (HR 2.84, 95% CI 2.22-3.65; P < 0.001)...Continue Reading

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Citations

Jul 3, 2020·European Heart Journal·Carina Blomström-Lundqvist
Oct 12, 2018·European Heart Journal. Quality of Care & Clinical Outcomes·Francis E Ugowe, Larry R Jackson
Jan 22, 2021·Journal of Cardiovascular Electrophysiology·Samuel J TuChristopher X Wong
Jan 1, 2021·European Heart Journal Supplements : Journal of the European Society of Cardiology·Eitaro Kodani, Masaharu Akao
Oct 16, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Moritake IguchiUNKNOWN Fushimi AF Registry Investigators
Aug 31, 2021·European Heart Journal·Frank L J VisserenUNKNOWN ESC Scientific Document Group
Sep 25, 2021·European Journal of Preventive Cardiology·Frank L J VisserenUNKNOWN ESC Scientific Document Group

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