Causes of Kawasaki Disease-From Past to Present

Frontiers in Pediatrics
Satoru Nagata

Abstract

Kawasaki disease (KD) is a multisystem vasculitis that primarily affects the coronary arteries of young children. The causes of KD remain a mystery. It is suspected that some sort of infectious agent is involved because KD has epidemicity and seasonality. That said, the incidence of the disease is high among Japanese people, so it can be speculated that the hosts may have some sort of genetic characteristic that leaves them susceptible to KD. Various theories regarding the etiology have been asserted, such as the infectious vasculitis theory, autoantigen theory, superantigen theory, and RNA virus theory; however, none of them have been able to overcome this epidemicity. Taking into consideration the knowledge gained from previous reports, the best scenario explaining the pathogenesis is "individuals with certain genetic backgrounds are affected by microorganisms which trigger KD." In this article, the pathogenesis of KD is discussed with a focus on the microorganisms mentioned above, along with the previous and current hypotheses as well as my own opinion.

References

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Citations

Oct 11, 2019·Current Opinion in Rheumatology·Francesca TirelliRolando Cimaz
Aug 3, 2020·Journal of Medical Virology·Alberto E Paniz-MondolfiEmilia M Sordillo
Aug 6, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Ho-Chang KuoLien-Hung Huang
Feb 13, 2020·Frontiers in Pediatrics·Seigo OkadaYuichi Ishikawa
Mar 3, 2021·European Journal of Pharmacology·Xuan LiHaitao Lv
May 4, 2021·Frontiers in Cardiovascular Medicine·Yuan-Yuan ZengFeng Chen
Jun 1, 2021·Frontiers in Pediatrics·Hsiao-Wen ChuYa-Chi Hsu
Jun 3, 2021·International Journal of Molecular Sciences·Heather Jackson On Behalf Of The Perform Consortium
Dec 23, 2021·Indian Journal of Pediatrics·Akanksha MahajanVirendra Kumar

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Methods Mentioned

BETA
PCR
biopsy
flow cytometry

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