PMID: 30819291Mar 2, 2019Paper

Caution: Increased Acute Kidney Injury in Enhanced Recovery after Surgery (ERAS) Protocols

The American Surgeon
Crystal P KoernerPatrick S Sullivan

Abstract

Minimizing perioperative fluid administration is a key component of enhanced recovery after surgery protocols (ERAS). Acute kidney injury (AKI) is a major cause of morbidity and mortality in hospitalized patients. Our aim was to assess the association of ERAS with the incidence and severity of AKI in patients undergoing elective colorectal surgery. In this single-study retrospective review, patients undergoing colorectal surgery from 2013 to 2017 were included. Primary endpoint was postoperative AKI. Secondary outcomes were hospital length of stay (LOS) and 30-day readmission. Baseline demographics and procedure types were similar between both groups. AKI was higher in the ERAS versus non-ERAS group (23 vs 9%; P = 0.002). Factors associated with increased risk of AKI on univariate regression included presence of preoperative cardiovascular risk factors (hazard ratio (HR) 3.5; 95% CI 1.3-9.7; P < 0.01), more complex colorectal operations (HR 5.1; 95% CI 1.6-16.1; P < 0.01), and management with an ERAS pathway (HR 2.9; 95% CI 1.5-5.8; P < 0.01). On multivariable analysis, ERAS remained a significant risk factor for developing AKI (HR 3.44; 95% CI 1.5-7.7; P < 0.01). ERAS patients had a shorter hospital LOS (3.9 vs 5.9 days, P < 0...Continue Reading

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