Cautions in the use of biomarkers of oxidative damage; the vascular and antioxidant effects of dark soy sauce in humans

Biochemical and Biophysical Research Communications
Chung-Yung J LeeB Halliwell

Abstract

Dark soy sauce (DSS) is a powerful antioxidant in vitro. We investigated whether this effect could occur in vivo and improve vascular function. Healthy human subjects were given DSS or placebo meals in a randomized, crossover study. Blood and urine were sampled before and 1, 2, 3, and 4h after the meal for F(2)-isoprostanes (total, free, and esterified) and 8OHdG measurements. Blood pressure, vascular augmentation index (AIx), and heart rate (HR) were also measured. Plasma total F(2)-isoprostanes significantly decreased 3h after placebo and the decrease was greater for DSS. Plasma free and esterified F(2)-isoprostanes were also significantly decreased after DSS. Both placebo and DSS meals increased urinary F(2)-isoprostanes at 1h but not thereafter, and lowered urinary 8OHdG levels, DBP and AIx, and increased HR. We conclude that DSS decreases lipid peroxidation in vivo. However, oxidative damage biomarkers changed after the placebo meal, a phenomenon to consider when designing interventional studies.

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Citations

Dec 17, 2009·Antioxidants & Redox Signaling·Barry Halliwell, Chung Yung J Lee
Oct 26, 2010·Antioxidants & Redox Signaling·Shazib Pervaiz
Aug 25, 2011·Journal of Medicinal Food·Changwe MashilipaNessar Ahmed
Jan 30, 2009·Journal of Clinical Biochemistry and Nutrition·George A AsareChristiana P Kahler-Venter
Jan 30, 2008·Free Radical Biology & Medicine·Chung-Yung J LeeBarry Halliwell
Apr 28, 2012·Nutrition Reviews·Barry Halliwell
Dec 5, 2009·Critical Reviews in Clinical Laboratory Sciences·Daniela GiustariniRanieri Rossi
Feb 23, 2010·Biochemical and Biophysical Research Communications·John M C Gutteridge, Barry Halliwell
Dec 30, 2008·Free Radical Biology & Medicine·Barry Halliwell
Nov 27, 2007·Free Radical Biology & Medicine·Chutima MatayatsukBarry Halliwell
Feb 7, 2014·Critical Reviews in Food Science and Nutrition·Teresa Petrosino, Mauro Serafini
Apr 25, 2007·Free Radical Research·Huansong WangBarry Halliwell
Sep 26, 2009·Toxicology Mechanisms and Methods·Zhang Xichun, Zhang Min'ai
Mar 17, 2012·British Journal of Clinical Pharmacology·Barry Halliwell
May 30, 2020·International Journal of Molecular Sciences·Melanie GrailleNancy B Hopf
Jul 28, 2020·Antioxidants·Gianluca Rizzo
Feb 8, 2019·Experimental Biology and Medicine·Flora S ParkCaroline A Rickards
Sep 30, 2019·Free Radical Biology & Medicine·Emil List LarsenHenrik Enghusen Poulsen
Sep 1, 2013·Comprehensive Reviews in Food Science and Food Safety·Alaa El-Din A BekhitEric N Ponnampalam
Oct 16, 2020·Free Radical Biology & Medicine·Barry Halliwell

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