Cav3.1 overexpression is associated with negative characteristics and prognosis in non-small cell lung cancer

Oncotarget
Aleksi SuoDGwyn Bebb

Abstract

Voltage-gated calcium channels (VGCC) have been found to be differentially expressed in several different tumor types, but their role in tumor growth, malignant invasion, metastases and impact on clinical outcomes has not been clarified. From a cohort database of 193 patients with early-stage NSCLC, 163 formalin-fixed paraffin-embedded specimens were available for analysis to construct tissue microarrays. Cav3.1 protein expression was detected using fluorescence immunohistochemistry, and quantified using automated image acquisition and analysis. Among the cohort of 193 NSCLC patients, adenocarcinoma (53.9%) and squamous cell carcinoma (SCC) (30.1%) were the most common histologies. There was no difference between SCC and non-SCC subtypes in overall survival (OS) or relapse-free survival (RFS); 74.2 vs 90.1 months (p= 0.543) and 48.8 vs 52.6 months (p= 0.766), respectively. T-type VGCC 3.1 (Cav3.1) overexpression was assessed by tissue microarray immunohistochemistry analysis from 163 available patient samples. Eighteen (11.0%) NSCLC primaries were found to have Cav3.1 overexpression levels, and were significantly associated with SCC histology (p< 0.001), larger tumor size (p< 0.001) and later stage disease at diagnosis (p= 0.01...Continue Reading

References

Jul 21, 1998·JAMA : the Journal of the American Medical Association·M E MullinsJ Stump
Jan 11, 2002·The New England Journal of Medicine·Joan H SchillerUNKNOWN Eastern Cooperative Oncology Group
Jul 3, 2003·Nature Reviews. Molecular Cell Biology·Michael J BerridgeH Llewelyn Roderick
Sep 21, 2004·Glia·Isabelle LatourGerald W Zamponi
Nov 29, 2005·Nature Neuroscience·Christophe AltierGerald W Zamponi
Mar 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael L MolineuxRay W Turner
Jun 13, 2006·Cell Calcium·Amith Panner, Robert D Wurster
Jun 27, 2006·Cell Calcium·Philippe LoryJean Chemin
Jun 23, 2007·Nature Reviews. Cancer·Gregory R MonteithSarah J Roberts-Thomson
Jan 12, 2008·Pflügers Archiv : European journal of physiology·Larissa LipskaiaAnne-Marie Lompré
May 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giorgio Vittorio ScagliottiDavid Gandara
Feb 20, 2010·Trends in Molecular Medicine·Natalia PrevarskayaYaroslav Shuba
Jun 18, 2010·Journal of the National Cancer Institute·Xia DingYizheng Wang
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 31, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shannon OtsukaD Gwyn Bebb
Jan 21, 2012·Pigment Cell & Melanoma Research·A DasC Cantí
Feb 23, 2012·British Journal of Pharmacology·Giorgio SantoniMassimo Nabissi
Jul 24, 2012·The Journal of Biological Chemistry·Gregory R MonteithSarah J Roberts-Thomson
Oct 30, 2012·Gynecologic Oncology·Jorge EscobarMartin Köbel
Dec 20, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E E VokesT G Karrison
Jan 11, 2014·Pflügers Archiv : European journal of physiology·Yuan ZhangJin Tao
Jun 3, 2014·Molecular Brain·Chris BladenGerald W Zamponi
Aug 27, 2014·Frontiers in Oncology·Grzegorz J KorpantyNatasha B Leighl
Feb 25, 2015·BioMed Research International·A MaciàC Cantí
Apr 9, 2015·Frontiers in Cellular Neuroscience·Alisa Litan, Sigrid A Langhans
Jun 28, 2016·European Biophysics Journal : EBJ·Paul J Buchanan, Karen D McCloskey

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Jun 23, 2020·Oncology Letters·Michał PudereckiBarbara Marzec-Kotarska

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Methods Mentioned

BETA
surgical resection
xenograft

Software Mentioned

HistoRX AQUAnalysis

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