CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamus.

The Journal of Physiology
Pavle M JoksovicSlobodan M Todorovic

Abstract

Although T-type Ca(2+) channels in the thalamus play a crucial role in determining neuronal excitability and are involved in sensory processing and pathophysiology of epilepsy, little is known about the molecular mechanisms involved in their regulation. Here, we report that reducing agents, including endogenous sulfur-containing amino acid l-cysteine, selectively enhance native T-type currents in reticular thalamic (nRT) neurons and recombinant Ca(V)3.2 (alpha1H) currents, but not native and recombinant Ca(V)3.1 (alpha1G)- and Ca(V)3.3 (alpha1I)-based currents. Consistent with this data, T-type currents of nRT neurons from transgenic mice lacking Ca(V)3.2 channel expression were not modulated by reducing agents. In contrast, oxidizing agents inhibited all native and recombinant T-type currents non-selectively. Thus, our findings directly demonstrate that Ca(V)3.2 channels are the main molecular substrate for redox regulation of neuronal T-type channels. In addition, because thalamic T-type channels generate low-threshold Ca(2+) spikes that directly correlate with burst firing in these neurons, differential redox regulation of these channels may have an important function in controlling cellular excitability in physiological and...Continue Reading

References

Jan 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H LandoltC G Honegger
May 4, 1990·Science·J W OlneyJ Labruyere
Jun 1, 1989·Journal of Neurochemistry·H J KellerM Cuénod
Dec 1, 1988·Annals of Neurology·R N Auer, B K Siesjö
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Jan 1, 1997·Annual Review of Neuroscience·D A McCormick, T Bal
Mar 1, 1996·Neurochemical Research·G A MathisenR E Paulsen
Dec 12, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M E SulimanJ Bergström
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·R R LlinásP P Mitra
Feb 24, 2001·Pflügers Archiv : European journal of physiology·I M FearonC Peers
Jun 25, 2002·Biophysical Journal·Juan Carlos GomoraEdward Perez-Reyes
Aug 17, 2002·Trends in Neurosciences·Stuart A LiptonLaurie A Bankston
Nov 25, 2003·Science·Chien-Chang ChenKevin P Campbell
Jun 18, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nathalie LerescheRégis C Lambert
Jan 13, 2005·British Journal of Pharmacology·Pavle M JoksovicSlobodan M Todorovic
May 13, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Iuliia VitkoEdward Perez-Reyes
Jun 2, 2005·Trends in Neurosciences·Mircea Steriade
Sep 24, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael T NelsonSlobodan M Todorovic

❮ Previous
Next ❯

Citations

Apr 5, 2008·Pflügers Archiv : European journal of physiology·Leigh Anne Swayne, Emmanuel Bourinet
Sep 10, 2010·Pflügers Archiv : European journal of physiology·Maria KarmazinovaLubica Lacinova
Jul 3, 2013·Molecular Neurobiology·Jeonghan LeeSlobodan M Todorovic
Apr 9, 2011·The British Journal of Nutrition·Jen-Yin ChenMiao-Lin Hu
Aug 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Simone AstoriAnita Lüthi
Oct 24, 2012·Population Health Management·Jen-Yin ChenMiao-Lin Hu
Jul 20, 2010·Clinical and Experimental Pharmacology & Physiology·Guanghua TangRui Wang
Nov 29, 2008·Molecular Pharmacology·Peihan OrestesSlobodan M Todorovic
Feb 22, 2012·Science Translational Medicine·Elizabeth TringhamTerrance P Snutch
Mar 12, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Peter R StregeGianrico Farrugia
Jul 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Megan O JacusSlobodan M Todorovic
Apr 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John D GraefDwayne W Godwin
Apr 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeanne T PazJohn R Huguenard
Jul 31, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Woo Yong LeeSlobodan M Todorovic
Jan 23, 2014·Pflügers Archiv : European journal of physiology·Barbara DziegielewskaJaroslaw Dziegielewski
Feb 13, 2014·Pflügers Archiv : European journal of physiology·Eunji Cheong, Hee-Sup Shin
Oct 29, 2013·Antioxidants & Redox Signaling·Slobodan M Todorovic, Vesna Jevtovic-Todorovic
Sep 7, 2011·The Biochemical Journal·Cécile HilaireFrédérique Scamps
Dec 9, 2010·Channels·Stuart M Cain, Terrance P Snutch
Jul 31, 2012·Cell Calcium·Luca MunaronDaniele Mancardi
Dec 18, 2013·Neurobiology of Aging·Shawn N WatsonWillem C Wildering
Sep 15, 2016·Scientific Reports·Dalia AlansaryBarbara A Niemeyer
Mar 11, 2009·The Journal of Physiology·Konstantin L Levitsky, José López-Barneo
Jul 26, 2017·Channels·Stuart M CainTerrance P Snutch
Feb 9, 2007·Journal of Neurophysiology·Pavle M JoksovicSlobodan M Todorovic
May 31, 2007·The Journal of Biological Chemistry·Michael E HildebrandTerrance P Snutch
Feb 12, 2010·American Journal of Physiology. Cell Physiology·K A AromolaranE S Piedras-Rentería
Aug 1, 2013·Physiological Reviews·Eunji Cheong, Hee-Sup Shin
May 15, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hannah E BoycottChris Peers
Jun 2, 2020·Journal of Neuroscience Research·Shiyi Wang, Constanza J Cortes
Feb 11, 2011·British Journal of Pharmacology·Slobodan M Todorovic, Vesna Jevtovic-Todorovic
Apr 14, 2011·The Journal of Physiology·Rui Wang, Gary R Lewin
May 9, 2012·Journal of Cellular and Molecular Medicine·Elia RanzatoBruno Burlando
Feb 6, 2018·Free Radical Biology & Medicine·Mia Y Bothwell, Martha U Gillette
Feb 19, 2013·Biochimica Et Biophysica Acta·Eunji Cheong, Hee-Sup Shin
Mar 7, 2012·Biochemical Pharmacology·M ChevalierJ P Savineau
Feb 16, 2010·Neurobiology of Aging·Shawn N WatsonWillem C Wildering

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved