PMID: 9187993Jun 1, 1997Paper

Caval occlusion alters the shape of the ischemic and nonischemic pressure-length loop

Journal of Cardiothoracic and Vascular Anesthesia
V PiriouP Foëx

Abstract

The effects of changes in preload on paradoxical myocardial wall motion during ischemia have been previously studied. However, the studies have been performed using slow volume changes. It was decided to study the effects of fast changes in preload, which would occur during caval occlusion, on the regional pressure-length loops during ischemia. Retrospective trial. Experimental animal laboratory in a university medical center. Ten anesthetized adult dogs. In an open chest preparation, regional ischemia was achieved by occluding the left anterior descending coronary artery for 10 minutes, with sudden caval occlusions being performed to assess the influence of preload on wall motion. Left ventricular pressure and regional segmental lengths were measured. During caval occlusion, beat by beat, percent postsystolic shortening and percent systolic bulging in the ischemic region, percent isovolumetric shortening in the nonischemic region, and percent systolic shortening in both regions were calculated. Caval occlusion significantly decreased the end-diastolic pressure (12.62 +/- 1.02 to 3.39 +/- 0.59 mmHg) and length. In the ischemic area, although systolic shortening became more negative (-1.8 +/- 0.79% to -9.65 +/- 1.08%), postsysto...Continue Reading

References

Mar 1, 1976·Annals of Internal Medicine·W Grossman, L P McLaurin
Dec 1, 1991·The Tohoku Journal of Experimental Medicine·K ShiratoT Takishima
Nov 1, 1991·Journal of the American College of Cardiology·G JondeauC Eng
Mar 1, 1991·Journal of the American College of Cardiology·A SafwatP Foëx

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