Caveolae as Potential Hijackable Gates in Cell Communication

Frontiers in Cell and Developmental Biology
Maria DudãuMihail E Hinescu

Abstract

Caveolae are membrane microdomains described in many cell types involved in endocytocis, transcytosis, cell signaling, mechanotransduction, and aging. They are found at the interface with the extracellular environment and are structured by caveolin and cavin proteins. Caveolae and caveolins mediate transduction of chemical messages via signaling pathways, as well as non-chemical messages, such as stretching or shear stress. Various pathogens or signals can hijack these gates, leading to infectious, oncogenic and even caveolin-related diseases named caveolinopathies. By contrast, preclinical and clinical research have fallen behind in their attempts to hijack caveolae and caveolins for therapeutic purposes. Caveolae involvement in human disease is not yet fully explored or understood and, of all their scaffold proteins, only caveolin-1 is being considered in clinical trials as a possible biomarker of disease. This review briefly summarizes current knowledge about caveolae cell signaling and raises the hypothesis whether these microdomains could serve as hijackable "gatekeepers" or "gateways" in cell communication. Furthermore, because cell signaling is one of the most dynamic domains in translating data from basic to clinical re...Continue Reading

References

Nov 1, 1978·Journal of Ultrastructure Research·G Gabella
Feb 21, 1992·Cell·K G RothbergR G Anderson
May 1, 1968·The Journal of Cell Biology·R R Bruns, G E Palade
Jun 30, 1995·The Journal of Biological Chemistry·S LiM P Lisanti
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·A J KoleskeM P Lisanti
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R G Anderson
Apr 18, 1997·The Journal of Biological Chemistry·T R BilderbackR T Dobrowsky
Oct 3, 1998·The Journal of Biological Chemistry·M YamamotoY Ishikawa
Mar 2, 1999·Biochemical and Biophysical Research Communications·C RacineJ Couet
Jul 6, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·J Thyberg
Mar 10, 2001·The American Journal of Pathology·K WiechenU Schneider
Mar 27, 2001·Journal of Cellular Physiology·K WheatonK Riabowol
Jul 18, 2001·The Journal of Biological Chemistry·B RazaniM P Lisanti
Oct 13, 2001·Trends in Molecular Medicine·F GalbiatiM P Lisanti
Jan 19, 2002·Journal of Virology·Varpu MarjomäkiJyrki Heino
Mar 9, 2002·Molecular and Cellular Biology·Babak RazaniMichael P Lisanti
Jul 18, 2002·Urologia Internationalis·Takashi KasaharaKota Takahashi
Jul 23, 2002·Molecular Biology of the Cell·Daniela VolonteFerruccio Galbiati
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Dan PredescuAsrar B Malik

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Methods Mentioned

BETA
electron microscopy
confocal microscopy
confocal microscopy. ”
GTPases

Clinical Trials Mentioned

NCT01426529
NCT04233814
NCT02874430
NCT01229501
NCT01878695
NCT01746225
NCT01641783
NCT03915314
NCT02701348
NCT00371254

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