Caveolin-1 affects tumor drug resistance in esophageal squamous cell carcinoma by regulating expressions of P-gp and MRP1

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Song ZhangSaijun Mo

Abstract

Esophageal squamous cell carcinoma (ESCC) is the most common cancer in China, and multidrug resistance (MDR) remains one of the biggest problems in ESCC chemotherapy. In this study, we aimed to investigate the mechanism of Caveolin-1, an integral membrane protein, on regulating ESCC MDR. First, immunohistochemistry was used to check the protein expression of Caveolin-1, MDR-related protein of P-glycoprotein (P-gp), and multidrug resistance protein 1 (MRP1) in 84 pathologically characterized ESCC tissues, matched adjacent tumor, and adjacent normal-looking tissues. The results showed that Caveolin-1 expression level was elevated in ESCC tissues than that of matched adjacent tumor and adjacent normal-looking tissues (P < 0.05), and the expression of Caveolin-1 has close correlation with P-gp and MRP1 during tumor genesis of ESCC (P = 0.034, P = 0.009, respectively). Then, Caveolin-1 overexpression and knockdown were used to investigate its effect on expressions of P-gp and MRP1 in ESCC cell line Ec9706. The messenger RNA (mRNA) and protein expression levels of P-gp and MRP1 were checked by real-time quantitative reverse transcription-PCR (qRT-PCR) and Western blot (WB). The results showed that Caveolin-1 overexpression significan...Continue Reading

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Citations

Jun 21, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fang ZhouHong Lu
Mar 16, 2018·International Journal of Molecular Sciences·David VranaPavel Soucek
Jan 9, 2019·The Journal of International Medical Research·Juan LiYu-Xiang Wang
Jan 5, 2017·Drug Delivery and Translational Research·Jamie F LuMary Bebawy
Sep 29, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Bin DuHanchun Yao
Aug 27, 2021·Carcinogenesis·Liwei PangJing Kong

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