Caveolin-1 inhibits breast cancer growth and metastasis

Oncogene
Erica K SloanRobin L Anderson

Abstract

Caveolin-1 was identified in a screen for genes involved in breast cancer progression. Caveolin-1 is the major protein component of caveolae, flask-shaped invaginations found in a number of different cell types. Using an orthotopic model of spontaneous breast cancer metastasis, caveolin-1 was found to be expressed in low and non-metastatic primary tumors, but at much lower levels in highly metastatic 4T1.2 and 4T1.13 tumors. Exogenous expression of caveolin-1 at moderate levels in 4T1.2 cells was sufficient to suppress primary tumor growth after inoculation of cells into the mammary gland. Expression of high levels of caveolin-1 also inhibited subsequent metastasis to distant organs. Cells expressing high levels of caveolin-1 showed reduced capacity to invade Matrigel, diminished response to laminin-1 stimulation and decreased metastasis to lung and bone. This study provides the first functional evidence that caveolin-1 regulates primary breast tumor growth and spontaneous metastasis of breast cancer.

References

Mar 1, 1992·Fertility and Sterility·J A StaffaV Miller
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·M MurataK Simons
Jan 1, 1994·Cold Spring Harbor Symposia on Quantitative Biology·R SagerP Pemberton
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·J C ZenklusenC J Conti
Nov 15, 1996·The Journal of Biological Chemistry·E J SmartR G Anderson
Jul 20, 1999·Clinical & Experimental Metastasis·M LelekakisR L Anderson
Aug 14, 1999·Science·F G Giancotti, E Ruoslahti
Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·E Felley-BoscoA F Quest
Mar 10, 2001·The American Journal of Pathology·K WiechenU Schneider
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·K Simons, D Toomre
Jul 18, 2001·The Journal of Biological Chemistry·B RazaniM P Lisanti
Dec 1, 2001·Expert Opinion on Biological Therapy·T C ThompsonD Kadmon
Mar 9, 2002·Molecular and Cellular Biology·Babak RazaniMichael P Lisanti
Jun 1, 2002·The Journal of Biological Chemistry·Makoto Kanzaki, Jeffrey E Pessin
Oct 12, 2002·Journal of Cell Science·Dorothy I MundyGeorge S Bloom

❮ Previous
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Citations

Feb 4, 2010·Apoptosis : an International Journal on Programmed Cell Death·Varisa PongrakhananonPithi Chanvorachote
Mar 17, 2006·Breast Cancer Research and Treatment·Socorro María Rodríguez PinillaJosé Palacios
May 29, 2008·Cancer Metastasis Reviews·Jacky G GoetzIvan R Nabi
Jan 30, 2008·Journal of Mammary Gland Biology and Neoplasia·Kay-Uwe Wagner, Hallgeir Rui
Jan 22, 2013·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Mitsuru Futakuchi, Rakesh K Singh
Jun 9, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maria R Tosi, Vitaliano Tugnoli
Oct 7, 2010·The Journal of Biological Chemistry·Sudjit LuanpitpongPithi Chanvorachote
Jul 24, 2013·Journal of Medicinal Food·Eliana Noelia AlonsoGabriela Andrea Balogh
Jun 8, 2006·Journal of the National Cancer Institute·Jaime R MerchanVikas P Sukhatme
May 19, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·David W L Ma
Sep 4, 2007·Breast Cancer Research : BCR·Yunpeng SuArthur E Frankel
Dec 29, 2009·Frontiers in Bioscience (Landmark Edition)·Puspa Raj PandeyKounosuke Watabe
Mar 1, 2012·Genetics and Molecular Research : GMR·D A P C ZuccariC Leonel
Jan 23, 2014·Journal of Translational Medicine·Yu GuLisong Teng
Mar 5, 2014·Clinical & Experimental Metastasis·Leonidas AlevizosGeorge Zografos
Oct 26, 2005·Breast Cancer Research and Treatment·Gert G Van den EyndenKenneth L van Golen
Apr 28, 2006·Clinical & Experimental Metastasis·Galina S Radunsky, Kenneth L van Golen
Nov 15, 2011·Annual Review of Pathology·Federica SotgiaMichael P Lisanti
May 1, 2007·Cell and Tissue Research·Catherine Hue-BeauvaisMichèle Ollivier-Bousquet
Aug 15, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xixue ZhaoLinghai Zhang
Sep 1, 2009·Current Breast Cancer Reports·Shaveta Vinayak, Allison W Kurian
Sep 9, 2015·Biomedical Journal·Christophe Lamaze, Stéphanie Torrino
Sep 20, 2006·Expert Opinion on Therapeutic Targets·Kenneth L van Golen
Nov 15, 2014·International Journal of Molecular Sciences·Cheng DuManjiang Xie
Feb 17, 2009·Cancer Investigation·Ferdinando Mannello, Gaetana A Tonti
Jan 7, 2015·Journal of Cellular Biochemistry·Madhura JoglekarKenneth L van Golen
Feb 9, 2016·European Journal of Pharmacology·Farideh A JavidAlessia Ligresti
Mar 22, 2008·Trends in Endocrinology and Metabolism : TEM·Keith R Solomon, Michael R Freeman
Jan 19, 2008·The American Journal of Pathology·Caterina BiancoDavid S Salomon
Jun 28, 2007·Cancer·Ila TamaskarMing Zhou
Aug 23, 2008·International Journal of Cancer. Journal International Du Cancer·Laura C HautalaHannu Koistinen
Mar 5, 2008·Journal of Cellular and Molecular Medicine·Candice M Thomas, Eric J Smart

❮ Previous
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