PMID: 9008709Jan 13, 1997Paper

Caveolin-3 associates with developing T-tubules during muscle differentiation

The Journal of Cell Biology
R G PartonE Stang

Abstract

Caveolae, flask-shaped invaginations of the plasma membrane, are particularly abundant in muscle cells. We have recently cloned a muscle-specific caveolin, termed caveolin-3, which is expressed in differentiated muscle cells. Specific antibodies to caveolin-3 were generated and used to characterize the distribution of caveolin-3 in adult and differentiating muscle. In fully differentiated skeletal muscle, caveolin-3 was shown to be associated exclusively with sarcolemmal caveolae. Localization of caveolin-3 during differentiation of primary cultured muscle cells and development of mouse skeletal muscle in vivo suggested that caveolin-3 is transiently associated with an internal membrane system. These elements were identified as developing transverse-(T)-tubules by double-labeling with antibodies to the alpha 1 subunit of the dihydropyridine receptor in C2C12 cells. Ultrastructural analysis of the caveolin-3-labeled elements showed an association of caveolin-3 with elaborate networks of interconnected caveolae, which penetrated the depths of the muscle fibers. These elements, which formed regular reticular structures, were shown to be surface-connected by labeling with cholera toxin conjugates. The results suggest that caveolin-...Continue Reading

References

Jul 5, 1978·Cell and Tissue Research·G Gabella, D Blundell
Nov 1, 1978·Journal of Ultrastructure Research·G Gabella
Jan 1, 1977·Tissue & Cell·S SchiaffinoS Sartore
Jan 1, 1976·Tissue & Cell·L Prescott, M W Brightman
Feb 1, 1975·The Journal of Cell Biology·C Franzini-ArmstrongG Pilar
Feb 21, 1992·Cell·K G RothbergR G Anderson
May 1, 1991·Developmental Biology·B E FlucherM P Daniels
Aug 1, 1984·Journal of the Neurological Sciences·T MiikeT Ishitsu
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·M MurataK Simons
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·A M FraR G Parton
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·M SargiacomoM P Lisanti
Sep 8, 1995·Science·R G Parton, K Simons
Jun 30, 1995·The Journal of Biological Chemistry·S LiM P Lisanti
Dec 1, 1994·The Journal of Cell Biology·R G PartonK Simons
Jun 6, 1994·FEBS Letters·T V KurzchaliaS Monier
Feb 1, 1994·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R G Parton
Mar 1, 1993·The Journal of Cell Biology·T Fujimoto
Nov 27, 1995·FEBS Letters·M Way, R G Parton
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·P E SchererM P Lisanti
Aug 1, 1996·Current Opinion in Cell Biology·R G Parton
Jul 1, 1994·Trends in Cell Biology·M P LisantiM Sargiacomo
Mar 1, 1993·Trends in Cell Biology·R G Anderson

❮ Previous
Next ❯

Citations

Sep 8, 2012·Cellular and Molecular Life Sciences : CMLS·W FullerK J Wypijewski
Jan 7, 2011·Pediatric Cardiology·David M Roth, Hemal H Patel
Jan 25, 2008·Pflügers Archiv : European journal of physiology·Michael KristensenCarsten Juel
Oct 13, 2006·Cell and Tissue Research·Claudia S MermelsteinManoel L Costa
Jun 14, 2005·Pharmacology & Therapeutics·R SchulzJ-L Balligand
Nov 2, 2001·Atherosclerosis·L S SleerK K Stanley
Mar 20, 2003·Brain Research. Developmental Brain Research·Dong Hoon ShinWang Jae Lee
Sep 12, 2001·Advanced Drug Delivery Reviews·S MatveevE J Smart
Oct 1, 1998·Cellular Signalling·A SchlegelM P Lisanti
Aug 1, 1997·Current Opinion in Cell Biology·T Harder, K Simons
Aug 17, 1999·Current Opinion in Cell Biology·T V Kurzchalia, R G Parton
Feb 1, 2003·Trends in Cell Biology·Bo van DeursKirsten Sandvig
Jul 4, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Glen F TibbitsFranklin Sedarat
Dec 9, 2000·Biochimica Et Biophysica Acta·C J Fielding, P E Fielding
Oct 13, 2001·Trends in Molecular Medicine·F GalbiatiM P Lisanti
Feb 4, 2003·Nature Reviews. Molecular Cell Biology·Robert G Parton
Jan 24, 2013·Nature Reviews. Molecular Cell Biology·Robert G Parton, Miguel A del Pozo
Oct 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lama Al-QusairiAnna Buj-Bello
Nov 26, 2008·The Journal of Biological Chemistry·Chuanxi CaiJianjie Ma
May 9, 2006·Antioxidants & Redox Signaling·Sang Chul Park
Sep 10, 2004·Molecular Biology of the Cell·Vilja PietiäinenTimo Hyypiä
Jan 25, 2013·Cardiovascular Research·Julia GorelikSian E Harding
Oct 24, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ashish MehtaWinston Shim
Feb 28, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Valeria BarresiGaetano Barresi
Mar 14, 2000·Molecular and Cellular Biology·A ApolloniJ F Hancock
May 9, 2002·Molecular and Cellular Biology·Federica SotgiaMichael P Lisanti
Oct 6, 1998·Annual Review of Biochemistry·R G Anderson
Nov 1, 2001·Annual Review of Cell and Developmental Biology·F M BrodskyD E Wakeham
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·S F Steinberg, L L Brunton
Oct 5, 2007·Annual Review of Pharmacology and Toxicology·Hemal H PatelPaul A Insel
Feb 5, 2010·American Journal of Physiology. Cell Physiology·Cheng LiuMichael Hadjiargyrou
Jun 17, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Ayanna S AugustusMichael P Lisanti
Dec 6, 2001·The Journal of Clinical Investigation·B Razani, M P Lisanti
Jul 30, 2011·Skeletal Muscle·Lama Al-Qusairi, Jocelyn Laporte
Mar 9, 2004·Genome Biology·Terence M Williams, Michael P Lisanti

❮ Previous
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