Cavitation dose painting for focused ultrasound-induced blood-brain barrier disruption

Scientific Reports
Yaoheng YangHong Chen

Abstract

Focused ultrasound combined with microbubble for blood-brain barrier disruption (FUS-BBBD) is a promising technique for noninvasive and localized brain drug delivery. This study demonstrates that passive cavitation imaging (PCI) is capable of predicting the location and concentration of nanoclusters delivered by FUS-BBBD. During FUS-BBBD treatment of mice, the acoustic emissions from FUS-activated microbubbles were passively detected by an ultrasound imaging system and processed offline using a frequency-domain PCI algorithm. After the FUS treatment, radiolabeled gold nanoclusters, 64Cu-AuNCs, were intravenously injected into the mice and imaged by positron emission tomography/computed tomography (PET/CT). The centers of the stable cavitation dose (SCD) maps obtained by PCI and the corresponding centers of the 64Cu-AuNCs concentration maps obtained by PET coincided within 0.3 ± 0.4 mm and 1.6 ± 1.1 mm in the transverse and axial directions of the FUS beam, respectively. The SCD maps were found to be linearly correlated with the 64Cu-AuNCs concentration maps on a pixel-by-pixel level. These findings suggest that SCD maps can spatially "paint" the delivered nanocluster concentration, a technique that we named as cavitation dose p...Continue Reading

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Citations

Jul 1, 2019·The Journal of the Acoustical Society of America·Pilsu KimTai-Kyong Song
Jul 1, 2020·Neural Regeneration Research·Jacopo Junio Valerio BrancaAlessandra Pacini
Dec 3, 2020·The Journal of the Acoustical Society of America·Krit Sujarittam, James J Choi
Nov 4, 2020·The Journal of the Acoustical Society of America·Ambre DaubaAnthony Novell
Mar 14, 2020·Ultrasound in Medicine & Biology·Klazina KooimanChristy K Holland
Jun 3, 2021·Cancers·Fabrizio MarcucciAndrés J M Ferreri

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Methods Mentioned

BETA
imaging techniques
fluorescence imaging

Software Mentioned

GraphPad Prism
Matlab

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