Cavity Carbon-Nanopipette Electrodes for Dopamine Detection

Analytical Chemistry
Cheng YangB Jill Venton

Abstract

Microelectrodes are typically used for neurotransmitter detection, but nanoelectrodes are not because there is a trade-off between spatial resolution and sensitivity that is dependent on surface area. Cavity carbon-nanopipette electrodes (CNPEs), with tip diameters of a few hundred nanometers, have been developed for nanoscale electrochemistry. Here, we characterize the electrochemical performance of CNPEs with fast-scan cyclic voltammetry (FSCV) for the first time. Dopamine detection using cavity CNPEs, with a depth equivalent to a few radii, is compared with that using open-tube CNPEs, an essentially infinite geometry. Open-tube CNPEs have very slow temporal responses that change over time as the liquid rises in the CNPE. However, a cavity CNPE has a fast temporal response to a bolus of dopamine that is not different from that of a traditional carbon-fiber microelectrode. Cavity CNPEs, with tip diameters of 200-400 nm, have high currents because the small cavity traps and increases the local dopamine concentration. The trapping also leads to an FSCV frequency-independent response and the appearance of cyclization peaks that are normally observed only with large concentrations of dopamine. CNPEs have high dopamine selectivity ...Continue Reading

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Citations

Jan 11, 2020·The Analyst·B Jill Venton, Qun Cao
Jan 11, 2020·The Analyst·Pumidech Puthongkham, B Jill Venton
Mar 11, 2020·Annual Review of Analytical Chemistry·Jacqueline D KeighronAnn-Sofie Cans
Mar 3, 2020·Bioelectrochemistry·Miriam MarquitanWolfgang Schuhmann
Feb 17, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Qun CaoB Jill Venton
Nov 28, 2019·Journal of the American Chemical Society·Rongrong PanMichael V Mirkin
Sep 11, 2019·Analytical Chemistry·Keke HuMichael V Mirkin
Sep 17, 2020·Journal of the American Chemical Society·Keke HuAndrew G Ewing
Nov 14, 2019·ACS Sensors·Cong XuLanqun Mao
Apr 13, 2019·Analytical Chemistry·Je Hyun BaeMichael V Mirkin
Aug 20, 2020·Nano Letters·Qun CaoB Jill Venton
Dec 11, 2021·Faraday Discussions·Qun CaoB Jill Venton
Dec 23, 2021·Faraday Discussions·Ayah J SyeedAshley E Ross
Dec 24, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Qizhang JiaKateri H DuBay

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