Cavum septi pellucidi in first-episode patients and young relatives at risk for schizophrenia

CNS Spectrums
Matcheri S KeshavanAmitabh Singh

Abstract

Studies on schizophrenia (SZ) have documented an increased presence of cavum septi pellucidi (CSP) in individuals suffering from the illness. Moreover, the presence of CSP has been cited in support of the early neurodevelopmental hypothesis in SZ. Our objective was to assess the magnetic resonance imaging (MRI) scans of first-episode patients and healthy controls to evaluate the frequency of CSP. The presence and the size of CSP were visually assessed on the MRI scans of 40 first-episode SZ patients, 19 nonpsychotic child and high-risk adolescent offspring of patients with SZ or schizoaffective disorder, and 59 controls. Our analysis revealed an absence of statistically significant differences in the occurrence of CSP between SZ patients, high-risk subjects, and controls. Even when the analysis was restricted to large CSP, no differences were found. Furthermore, no association between CSP and sex or handedness was observed. The absence of CSP abnormalities in first-episode SZ subjects might indicate that SZ is not characterized by developmentally mediated alterations in CSP. Also, family history of SZ might not increase likelihood for CSP.

References

Mar 1, 1969·Brain : a Journal of Neurology·C M Shaw, E C Alvord
Aug 26, 1995·Lancet·D R Weinberger
Oct 1, 1993·Psychiatry Research·L E DeLisiG Degreef
Jan 1, 1993·The Journal of Neuropsychiatry and Clinical Neurosciences·T F ScottW Rothfus
Feb 15, 1993·Biological Psychiatry·B BogertsS Masiar
Jan 1, 1996·The Journal of Neuropsychiatry and Clinical Neurosciences·P NopoulosN C Andreasen
Jun 1, 1996·Psychiatry and Clinical Neurosciences·T FukuzakoM Takigawa
May 20, 1999·Biological Psychiatry·R W McCarleyM E Shenton
Jun 1, 1999·Biological Psychiatry·J R DeQuardoJ W Pettegrew
Jan 5, 2000·The British Journal of Psychiatry : the Journal of Mental Science·K RaziL E DeLisi
Aug 2, 2000·Archives of General Psychiatry·R E GurR C Gur
Oct 2, 2001·The American Journal of Psychiatry·H HaginoH Seto

❮ Previous
Next ❯

Citations

Dec 21, 2006·European Archives of Psychiatry and Clinical Neuroscience·Ralf BrischBernhard Bogerts
May 26, 2017·PloS One·Hanwen LiuJingyuan Mao
Jul 4, 2019·The Journal of Neuropsychiatry and Clinical Neurosciences·Liu-Xian WangHong Yin
Jan 13, 2006·European Psychiatry : the Journal of the Association of European Psychiatrists·José Alexandre de Souza CrippaPhilip K McGuire
Oct 18, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·H W ThermenosL J Seidman
Jul 13, 2006·Expert Review of Neurotherapeutics·Veena Kumari, Michael Cooke

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuropsychiatry and Clinical Neurosciences
P NopoulosN C Andreasen
Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes
Richard I AvivAlan Valentine
© 2022 Meta ULC. All rights reserved