CB1 and CB2 cannabinoid receptor expression during development and in epileptogenic developmental pathologies

Neuroscience
E ZuroloE Aronica

Abstract

Recent data support the involvement of the endocannabinoid signaling in early brain development, as well as a key role of cannabinoid receptors (CBR) in pathological conditions associated with unbalanced neuronal excitability and inflammation. Using immunocytochemistry, we explored the expression and cellular pattern of CBR 1 and 2 (CB1 and CB2) during prenatal human cortical development, as well as in focal malformations of cortical development associated with intractable epilepsy (focal cortical dysplasia; cortical tubers in patients with the tuberous sclerosis complex and glioneuronal tumors). Strong CB1 immunoreactivity was detected in the cortical plate in developing human brain from the earliest stages tested (gestational week 9) and it persisted throughout prenatal development. Both cannabinoid receptors were not detected in neural progenitor cells located in the ventricular zone. Only CB1 was expressed in the subventricular zone and in Cajal-Retzius cells in the molecular zone of the developing neocortex. CB2 was detected in cells of the microglia/macrophage lineage during development. In malformations of cortical development, prominent CB1 expression was demonstrated in dysplastic neurons. Both CBR were detected in bal...Continue Reading

References

Jan 28, 1998·Journal of the American Academy of Child and Adolescent Psychiatry·P Rakic, P J Lombroso
Apr 29, 1998·Brain Research. Molecular Brain Research·H H McIntoshA C Howlett
Nov 13, 1998·Current Opinion in Neurobiology·M Frotscher
Aug 26, 1999·Life Sciences·J J Fernández-RuizJ A Ramos
Nov 27, 1999·Developmental Neuroscience·A HilbigW Bingaman
Jan 13, 2000·Trends in Neurosciences·J Fernández-RuizJ A Ramos
Sep 21, 2000·The European Journal of Neuroscience·N HájosT F Freund
Nov 10, 2001·Brain & Development·M Mizuguchi, S Takashima
Apr 22, 2003·Journal of Neuroscience Research·Carlos CepedaGary W Mathern
Sep 5, 2003·The Journal of Pharmacology and Experimental Therapeutics·Melisa J WallaceRobert J DeLorenzo
Oct 4, 2003·Science·Giovanni MarsicanoBeat Lutz
Mar 24, 2004·Neurology·A PalminiH V Vinters
Jul 28, 2004·Neuropharmacology·Hamed ShafaroodiAhmad Reza Dehpour
Nov 17, 2004·Neurotoxicity Research·Javier Fernández-RuizJosé A Ramos
Nov 26, 2004·Journal of Child Neurology·Francis J DiMario
Dec 18, 2004·Cancer Research·Kasem NithipatikomWilliam B Campbell
Jun 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·C BernardH Gozlan
Nov 24, 2005·Epilepsia·Annamaria Vezzani, Tiziana Granata
Dec 27, 2005·Current Drug Targets. CNS and Neurological Disorders·Ester Fride
Feb 18, 2006·Journal of Neuroimmunology·K BoerE Aronica
Jul 25, 2006·Neurobiology of Disease·T RavizzaE Aronica
Aug 9, 2006·Journal of Neurochemistry·Janka Held-FeindtRolf Mentlein
Sep 14, 2006·Pharmacological Reviews·Pál PacherGeorge Kunos
Oct 4, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Javier PalazuelosIsmael Galve-Roperh
Oct 10, 2006·The Journal of Comparative Neurology·Anne MonierCatherine Verney
Jan 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kang ChenIvan Soltesz
Jan 24, 2007·Brain Research·Aleksandra Ellert-MiklaszewskaLiliana Konarska
Feb 3, 2007·Journal of Neurophysiology·Elisa L HillBertrand Lambolez
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cristina BenitoJulián Romero

❮ Previous
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Citations

Oct 31, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Javier Díaz-AlonsoIsmael Galve-Roperh
Apr 27, 2013·PloS One·Natalia BattistaMauro Maccarrone
Nov 19, 2013·PloS One·Joseph BouskilaJean-François Bouchard
Oct 1, 2015·Genes, Brain, and Behavior·T T-Y LeeF S Lee
Apr 14, 2016·Pharmacology Research & Perspectives·Marta RubioJavier Fernández-Ruiz
Jan 20, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·W O RohofG E Boeckxstaens
Aug 29, 2012·British Journal of Pharmacology·R B LaprairieE M Denovan-Wright
May 1, 2013·The Journal of Comparative Neurology·Joseph BouskilaJean-François Bouchard
Sep 10, 2014·Neuroscience·H AmhaoulS Dedeurwaerdere
May 12, 2015·Neuroscience and Biobehavioral Reviews·Alejandro Higuera-MatasEmilio Ambrosio
Jan 13, 2015·Invertebrate Neuroscience : in·Elizabeth Hahn, Brian Burrell
May 19, 2017·Development, Growth & Differentiation·Francesca OltrabellaSu Guo
Jan 31, 2017·Annual Review of Pathology·Philip H Iffland, Peter B Crino
Aug 10, 2017·International Journal of Molecular Sciences·Ewa KozelaZvi Vogel
Jul 8, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Heidi C MeyerDylan G Gee
Sep 1, 2018·Journal of Neuropathology and Experimental Neurology·Linda K Friedman, Joann P Wongvravit
Nov 22, 2011·The Journal of Biological Chemistry·Javier PalazuelosIsmael Galve-Roperh
Jan 29, 2019·Frontiers in Pharmacology·Daniel García-RincónIsmael Galve-Roperh
Apr 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rui S RodriguesSara Xapelli
Dec 8, 2020·Journal of Developmental Origins of Health and Disease·Oyekoya T AyonrindeOyekunle K Ayonrinde
Jul 22, 2020·World Neurosurgery·Caitlin E HoffmanTheodore H Schwartz
Feb 15, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Javier Fernández-RuizManuel Guzmán
Oct 13, 2019·Trends in Neurosciences·Andrew F ScheyerOlivier J J Manzoni
May 23, 2021·Nature Reviews. Neuroscience·Anissa BaraYasmin L Hurd

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