CB1 and TRPV1 receptors mediate protective effects on colonic electrophysiological properties in mice

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Andrei SibaevM Storr

Abstract

CB1 and TRPV1 receptors modulate enteric neurotransmission and colonic inflammation. This study investigates early electrophysiological changes in distal colon of wild-type and receptor deficient mice after an inflammatory insult set by dinitrobenzene sulfonic acid (DNBS). Colitis was induced by DNBS in CB1(-/-) mice, TRPV1(-/-) mice, and their respective wild-type littermates. Electrophysiological properties consisting of membrane potentials and electrically induced inhibitory junction potentials (IJP) of circular smooth muscle cells were evaluated at different time points. Additionally a histological colitis severity score was evaluated in CB1(+/+) and CB1(-/-) mice 24 h after DNBS. Inflammation caused spontaneous atropine insensitive rhythmic action potentials in CB1(-/-) and TRPV1(-/-) mice but not in wild-type animals. This indicates that membrane stability is disturbed, which in turn indicates a lack of protective mechanisms. Focal electrical neuronal stimulation of the myenteric plexus induced IJP in the smooth muscle cells. Twenty-four hours after initiation of inflammation, the duration of the IJP is prolonged in all animals, indicating disturbances within neuromuscular interaction. In CB1(-/-) mice, it is interesting ...Continue Reading

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Citations

May 22, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Martin A StorrKeith A Sharkey
Feb 2, 2010·Pharmacology & Therapeutics·Angelo A Izzo, Keith A Sharkey
Nov 10, 2009·Pharmacology & Therapeutics·Khadija Alawi, Julie Keeble
Mar 14, 2007·Pharmacology & Therapeutics·Katarzyna StarowiczVincenzo Di Marzo
Apr 17, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G M MaweK A Sharkey
Dec 5, 2008·Alimentary Pharmacology & Therapeutics·M StorrS Brand
Aug 20, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M A StorrK A Sharkey
Mar 7, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D de FontgallandD A Wattchow
Jan 1, 2011·Pharmaceuticals·Asia Fernández-CarvajalAntonio Ferrer-Montiel
Dec 15, 2017·BioMed Research International·Hiroshi EguchiYoshikazu Shimomura
Aug 20, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yunna LeeEunok Im
May 2, 2009·Inflammatory Bowel Diseases·Martin A StorrKeith A Sharkey
Dec 3, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Silvia ZoppiJuan C Leza

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