CB1 Cannabinoid Agonist (WIN55,212-2) Within the Basolateral Amygdala Induced Sensitization to Morphine and Increased the Level of μ-Opioid Receptor and c-fos in the Nucleus Accumbens.

Journal of Molecular Neuroscience : MN
Marzieh MolaeiAbbas Haghparast

Abstract

The basolateral amygdala (BLA) is rich of CB1 cannabinoid receptors (CB1R) and has reciprocal connections with the nucleus accumbens (NAc) which is involved in opioid sensitization. In this study, effects of intra-BLA administration of CB1R agonist on sensitization to antinociceptive effect of morphine and changes in the levels of μ-opioid receptor (MOR), p-CREB, and c-fos in the NAc were investigated. Animals received intra-BLA microinjection of CB1R agonist (WIN55,212-2) once daily for 3 days consecutively (sensitization period). After 5 days free of drug, tail-flick test was performed before and after the administration of an ineffective dose of morphine. Afterward, the levels of MOR, p-CREB, and c-fos proteins were measured in the NAc by Western blot analysis. The results indicated that intra-BLA injection of WIN55,212-2 during sensitization period resulted in the induction of antinociceptive responses by ineffective dose of morphine and caused a significant increase in the MOR and c-fos levels but not p-CREB/CREB ratio in the NAc. These finding revealed that CB1 receptor agonist in the BLA induces development of morphine sensitization and increases expression of MOR in the NAc. It seems that c-fos is one of the important f...Continue Reading

References

Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A M GraybielH A Robertson
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·K L WidnellE J Nestler
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·J LiuF R Sharp
Sep 1, 1996·Journal of Lipid Mediators and Cell Signalling·R MechoulamA E Sulcova
Jul 1, 1997·The Journal of Neuropsychiatry and Clinical Neurosciences·L HeimerD S Zahm
Feb 7, 1998·Current Opinion in Neurobiology·E J Nestler
Dec 5, 1998·Neurochemistry International·K J Kovács
Jul 23, 1999·Annals of the New York Academy of Sciences·G F Koob
Dec 29, 1999·Brain Research·S P Welch, M Eads
Aug 3, 2001·Nature Reviews. Molecular Cell Biology·B Mayr, M Montminy
Aug 23, 2001·European Journal of Pharmacology·F E PontieriF R Patacchioli
Aug 17, 2002·Pharmacology & Therapeutics·J Michael Walker, Susan M Huang
Mar 26, 2003·Neuroscience·D ViganòD Parolaro
Oct 21, 2003·Nature Neuroscience·Colleen A McClung, Eric J Nestler
Aug 31, 2004·Journal of Neuroscience Research·Olivera Pluzarev, Subhash C Pandey
Sep 24, 2004·The European Journal of Neuroscience·Daniela ViganòTiziana Rubino
Dec 8, 2004·Critical Reviews in Neurobiology·Liana FattoreWalter Fratta
Jun 7, 2005·Pharmacology, Biochemistry, and Behavior·Liana FattoreWalter Fratta
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John McDaidT Celeste Napier
Feb 18, 2006·Trends in Neurosciences·Rafael MaldonadoFernando Berrendero
Apr 19, 2007·Clinical and Experimental Pharmacology & Physiology·Parisa HasaneinKazem Javanmardi
Apr 17, 2008·British Journal of Pharmacology·M SolinasD Piomelli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.