CbbR, the Master Regulator for Microbial Carbon Dioxide Fixation

Journal of Bacteriology
Andrew W Dangel, F R Tabita

Abstract

Biological carbon dioxide fixation is an essential and crucial process catalyzed by both prokaryotic and eukaryotic organisms to allow ubiquitous atmospheric CO2 to be reduced to usable forms of organic carbon. This process, especially the Calvin-Bassham-Benson (CBB) pathway of CO2 fixation, provides the bulk of organic carbon found on earth. The enzyme ribulose 1,5-bisphosphate (RuBP) carboxylase/oxygenase (RubisCO) performs the key and rate-limiting step whereby CO2 is reduced and incorporated into a precursor organic metabolite. This is a highly regulated process in diverse organisms, with the expression of genes that comprise the CBB pathway (the cbb genes), including RubisCO, specifically controlled by the master transcriptional regulator protein CbbR. Many organisms have two or more cbb operons that either are regulated by a single CbbR or employ a specific CbbR for each cbb operon. CbbR family members are versatile and accommodate and bind many different effector metabolites that influence CbbR's ability to control cbb transcription. Moreover, two members of the CbbR family are further posttranslationally modified via interactions with other transcriptional regulator proteins from two-component regulatory systems, thus a...Continue Reading

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Citations

Jul 6, 2017·Environmental Microbiology·Jianming YangCaroline S Harwood
Aug 8, 2018·Acta Crystallographica. Section F, Structural Biology Communications·Didel M MahoungaYong Liang Jiang
Feb 23, 2020·FEMS Microbiology Reviews·S Joke LambrechtWolfgang R Hess
Oct 28, 2019·Frontiers in Microbiology·Miriam DormeyerFabian M Commichau
Oct 4, 2017·Scientific Reports·Percival J GrahamDavid Sinton
Sep 1, 2017·FEMS Microbiology Letters·Di LiuOliver Mueller-Cajar
Feb 2, 2021·Trends in Biotechnology·Justin PanichSteven W Singer
Feb 13, 2021·The FEBS Journal·Evdokia-Anastasia GiannopoulouToshiya Senda
Feb 22, 2021·Current Opinion in Microbiology·James W Wilson

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