CBCT-based synthetic CT generation using deep-attention cycleGAN for pancreatic adaptive radiotherapy

Medical Physics
Yingzi LiuXiaofeng Yang

Abstract

Current clinical application of cone-beam CT (CBCT) is limited to patient setup. Imaging artifacts and Hounsfield unit (HU) inaccuracy make the process of CBCT-based adaptive planning presently impractical. In this study, we developed a deep-learning-based approach to improve CBCT image quality and HU accuracy for potential extended clinical use in CBCT-guided pancreatic adaptive radiotherapy. Thirty patients previously treated with pancreas SBRT were included. The CBCT acquired prior to the first fraction of treatment was registered to the planning CT for training and generation of synthetic CT (sCT). A self-attention cycle generative adversarial network (cycleGAN) was used to generate CBCT-based sCT. For the cohort of 30 patients, the CT-based contours and treatment plans were transferred to the first fraction CBCTs and sCTs for dosimetric comparison. At the site of abdomen, mean absolute error (MAE) between CT and sCT was 56.89 ± 13.84 HU, comparing to 81.06 ± 15.86 HU between CT and the raw CBCT. No significant differences (P > 0.05) were observed in the PTV and OAR dose-volume-histogram (DVH) metrics between the CT- and sCT-based plans, while significant differences (P < 0.05) were found between the CT- and the CBCT-based ...Continue Reading

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Citations

Dec 12, 2020·Journal of Applied Clinical Medical Physics·Tonghe WangXiaofeng Yang
Nov 13, 2020·International Journal of Radiation Oncology, Biology, Physics·Bastien RigaudKristy K Brock
May 13, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Ana Barragán-MonteroJohn A Lee
Jun 2, 2021·Physics in Medicine and Biology·Liyuan ChenJing Wang
May 17, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jinsoo UhChia-Ho Hua
May 17, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Yabo FuXiaofeng Yang
Aug 19, 2021·Medical Physics·Maria Francesca SpadeaJoao Seco
Sep 18, 2021·Physics in Medicine and Biology·Branimir RusanovMahsheed Sabet
Oct 16, 2021·Biomedical Physics & Engineering Express·Richard L J QiuXiaofeng Yang

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