Cbfa1/Runx2 expression in an ossifying basal cell carcinoma of the eyelid

Archives of Dermatological Research
Jeannette TothPecorella Irene

Abstract

A case of basal cell carcinoma (BCC) with intratumoural bone formation affecting the eyelid of a 77-year-old lady is described. Bone formation in BCCs is an uncommon event. We revised the 23 cases described in the literature: most of them occurred on the face. The pathophysiological mechanism responsible for ossification in cutaneous lesions remains unclear. The bone often develops adjacent to, or within hair follicles. We evaluated the immunohistochemical expression in the present case of Cbfa1/Runx2, an early marker for osteoblastic progenitor cells. A well-developed lamellar bone with adipose bone marrow was observed both in the superficial stroma and intratumourally. Cbfa1/Runx2 was localised in the osteocytes of the heterotopic bone and in the keratin cysts of the BCC. The expression of Cbfa1/Runx2 in the present BCC suggests a possible role of this protein in the induction of the heterotopic bone.

References

Oct 1, 1983·The British Journal of Dermatology·Y MerotJ H Saurat
May 1, 1982·International Journal of Dermatology·R S Tomsick, H Menn
Mar 1, 1981·The Journal of Investigative Dermatology·J H SauratS Balsan
Jan 1, 1993·Journal of Clinical Pathology·W F KnoxR Bonshek
Feb 1, 1993·The American Journal of Dermatopathology·F CottoniG Tedde
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·C ZengS W Hiebert
Aug 6, 1997·Journal of the National Cancer Institute·M R Gailani, A E Bale
Jun 19, 1998·Journal of the American Academy of Dermatology·A S Boyd, L E King
Feb 6, 1999·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·J S WalshH W Randle
Feb 23, 1999·The American Journal of Dermatopathology·T ShojiJ Bhawan
Nov 9, 2000·The British Journal of Dermatology·I KurokawaA Tsubura
Sep 5, 2002·Journal of Cellular Biochemistry·Toshihisa Komori
Feb 1, 2003·Journal of Surgical Oncology·Alan P KypsonHilliard F Seigler
Mar 5, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Antonius L J J BronckersMarten A Engelse
Aug 20, 2005·Journal of Cellular Physiology·Shirwin M PockwinseStephen J Doxsey
Jan 13, 2006·The British Journal of Dermatology·K S LeslieS T Donel
Aug 3, 2006·Journal of Clinical Pathology·K O AlsaadD Ghazarian
Apr 20, 2007·Molecular Biology of the Cell·Atsuko ShimoyamaToshiyuki Yoneda
Feb 12, 2008·Developmental Biology·Donald J GlotzerBjorn R Olsen

❮ Previous
Next ❯

Citations

Aug 24, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jane B LianGary S Stein
Dec 7, 2019·Ophthalmic Plastic and Reconstructive Surgery·Lauren R SchafferHans E Grossniklaus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.