CBP80-promoted mRNP rearrangements during the pioneer round of translation, nonsense-mediated mRNA decay, and thereafter

Cold Spring Harbor Symposia on Quantitative Biology
Lynne E MaquatYalan Tang

Abstract

In mammalian cells, two different messenger ribonucleoproteins (mRNPs) serve as templates for protein synthesis. Newly synthesized mRNPs bound by the cap-binding protein heterodimer CBP80-CBP20 (CBC) initially undergo a pioneer round of translation. One purpose of this round of translation is to ensure the quality of gene expression, as exemplified by nonsense-mediated messenger RNA (mRNA) decay (NMD). NMD largely functions to eliminate mRNAs that prematurely terminate translation, although NMD also contributes to proper gene control, and it targets CBC-bound mRNPs. CBC-bound mRNPs are remodeled to eukaryotic translation initiation factor (eIF)4E-bound mRNPs in steps that (1) are a consequence of the pioneer round of translation and (2) occur independently of translation. Rather than supporting NMD, eIF4E-bound mRNPs provide for the bulk of cellular protein synthesis and are the primary targets of mRNA decay mechanisms that conditionally regulate gene expression. Here, we overview cellular processes by which CBC-bound mRNPs are remodeled to eIF4E-bound mRNPs. We also describe the molecular movements of certain factors during NMD in view of the influential role of CBP80.

References

Jul 15, 1997·European Journal of Biochemistry·J D Lewis, E Izaurralde
Aug 29, 1997·The Journal of Biological Chemistry·A Haghighat, N Sonenberg
May 28, 1998·The Journal of Biological Chemistry·E AfoninaG N Pavlakis
Sep 8, 2001·Molecular Cell·C MazzaS Cusack
Jun 28, 2002·Molecular Cell·Caroline M Groft, Stephen K Burley
Jul 18, 2002·Current Biology : CB·Josée Dostie, Gideon Dreyfuss
Nov 16, 2002·Nature Structural Biology·Guillermo CaleroRichard A Cerione
May 26, 2004·Biochimica Et Biophysica Acta·Uwe Kühn, Elmar Wahle
Jul 3, 2004·Genome Research·Ben Lehner, Christopher M Sanderson
Sep 14, 2004·Nature Structural & Molecular Biology·Fabrice LejeuneLynne E Maquat
Nov 18, 2004·Molecular Cell·Leonie Unterholzner, Elisa Izaurralde
Sep 28, 2005·Nature Structural & Molecular Biology·Nao HosodaLynne E Maquat
Feb 2, 2006·Molecular and Cellular Biology·Jürgen WittmannHans-Martin Jäck
Apr 4, 2006·Molecular and Cellular Biology·Nao HosodaLynne E Maquat
Dec 28, 2006·Cell·Hong ChengRobin Reed
Mar 27, 2007·Cold Spring Harbor Symposia on Quantitative Biology·M C DerryN Sonenberg
Jul 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Zuo Zhang, Adrian R Krainer
Aug 3, 2007·Genes & Development·Olaf Isken, Lynne E Maquat
Nov 21, 2007·Molecular and Cellular Biology·Nihal G CakmakciWilliam F Marzluff
Dec 11, 2007·Nature Structural & Molecular Biology·Hala ChamiehHervé Le Hir

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Citations

Mar 13, 2013·Nature Reviews. Genetics·Michaela Müller-McNicoll, Karla M Neugebauer
May 15, 2013·Nature Structural & Molecular Biology·Sébastien Durand, Jens Lykke-Andersen
Jun 7, 2013·Nature Structural & Molecular Biology·Matthias W Hentze, Elisa Izaurralde
Feb 5, 2014·Biochemistry. Biokhimii︠a︡·I A EliseevaL P Ovchinnikov
Jan 15, 2014·Nucleic Acids Research·Hiroto IzumiMutsuhito Ohno
Aug 14, 2013·Journal of Biosciences·Satarupa Das, Biswadip Das
Feb 14, 2014·Critical Reviews in Biochemistry and Molecular Biology·Ivan N ShatskyIlya M Terenin
Sep 25, 2015·Plant Cell Reports·Yiming DaiLijia An
Sep 24, 2015·Nature Reviews. Molecular Cell Biology·Søren Lykke-Andersen, Torben Heick Jensen
May 3, 2014·Wiley Interdisciplinary Reviews. RNA·Callie P WigingtonAnita H Corbett
Jul 24, 2012·Biochemical Society Transactions·Matthew Brook, Nicola K Gray
Jul 19, 2013·Biochemical Society Transactions·Carson C Thoreen
Oct 20, 2012·Virus Research·Sylvain de BreyneThéophile Ohlmann
Mar 10, 2015·Biochimie·Christopher S Fraser
Mar 19, 2015·Annual Review of Biochemistry·Guramrit SinghMelissa J Moore
Sep 1, 2014·Translation·Théophile OhlmannMarcelo López-Lastra
Oct 30, 2012·Current Opinion in Structural Biology·Oscar Llorca
Jun 19, 2016·Nucleic Acids Research·Anand RamanathanSiu-Hong Chan
Nov 28, 2013·Annual Review of Genetics·Maximilian Wei-Lin Popp, Lynne E Maquat
Oct 18, 2005·Advances in Immunology·Dipanjan Chowdhury, Carl D Novina
Apr 8, 2017·Journal of Cell Science·Frédéric SaltelHélène Jacquemin-Sablon
Feb 12, 2019·Cellular and Molecular Life Sciences : CMLS·Paulo A Ferreira
Sep 3, 2020·Genes & Development·Xavier Rambout, Lynne E Maquat
Oct 10, 2020·Trends in Biochemical Sciences·Xavier Rambout, Lynne E Maquat
May 26, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Aldo BarreraMarcelo López-Lastra

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