CBX1 Indicates Poor Outcomes and Exerts Oncogenic Activity in Hepatocellular Carcinoma

Translational Oncology
Yu-Feng YangShu-Guang Su

Abstract

Dysregulation of chromobox proteins contributes to the progression of human diseases. CBX1 has been implicated in epigenetic control of chromatin structure and gene expression, but its role in human cancers remains largely unknown. Here we show that CBX1 exhibits oncogenic activities in hepatocellular carcinoma (HCC) and indicates poor outcomes. The expression of CBX1 was noticeably increased, at both mRNA and protein levels, in HCC tissues and cell lines, compared with the nontumorous ones. High CBX1 expression was significantly associated with larger tumor size, poor tumor differentiation and tumor vascular invasion. Patients with elevated expression of CBX1 were frequently accompanied with unfavorable overall and disease-free survivals in two independent cohorts consisting of 648 HCC cases. The prognostic value of CBX1 was further confirmed by stratified survival analyses. Multivariate cox regression model suggested CBX1 as an independent factor for overall survival (hazard ratio = 1.735, 95% confident interval: 1.342-2.244, P < .001). In vitro data demonstrated that CBX1 overexpression promoted cell proliferation and migration, whereas the knockdown of CBX1 resulted in the opposite phenotypes. Mechanistically, CBX1 interact...Continue Reading

Citations

Feb 6, 2019·International Journal of Molecular Sciences·Tomoyuki Honda, Md Arifur Rahman
May 29, 2021·Frontiers in Oncology·Jian ZhouTang Liu
Jun 13, 2021·Scientific Reports·Mengya HeRongguang Zhang

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Methods Mentioned

BETA
surgical resection
Transfection
PCR

Software Mentioned

Gene Set Enrichment Analysis ( GSEA )

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