CBX3/HP1γ promotes tumor proliferation and predicts poor survival in hepatocellular carcinoma

Aging
Xiaoping ZhongShijie Tang

Abstract

HP1γ, encoded by CBX3, is associated with cancer progression and patient prognosis. However, the prognostic value and functions of CBX3/HP1γ in hepatocellular carcinoma (HCC) remain unclear. Here, we performed a bioinformatics analysis using the Oncomine, TCGA and Human Protein Atlas databases, the Kaplan-Meier plotter, and the UALCAN web-portal to explore the expression and prognostic significance of CBX3/HP1γ in patients with different cancers, including liver cancer. HCC tissues and microarrays containing 354 samples were examined using immunohistochemical staining, quantitative real-time polymerase chain reaction, and Western blotting. CBX3-overexpression HCC cell lines were tested in proliferation assays to determine the function of CBX3/HP1γ. We found that CBX3/HP1γ was upregulated in many cancers and was associated with poor prognosis. Our results also revealed that CBX3/HP1γ is elevated in HCC tissues and is associated with malignant clinicopathological characteristics. Kaplan-Meier and Cox regression analyses verified that high CBX3/HP1γ expression is an independent and significant prognostic factor for reduced overall survival in HCC patients. Moreover, invitro functional assays showed that CBX3/HP1γ overexpression pr...Continue Reading

References

Jan 5, 2002·DNA Sequence : the Journal of DNA Sequencing and Mapping·D O JonesP B Singh
Jun 12, 2002·Molecular Biology of the Cell·Xin ChenPatrick O Brown
Jan 17, 2007·Genome Biology·Gwen LomberkRaul Urrutia
Oct 17, 2008·The New England Journal of Medicine·Yujin HoshidaTodd R Golub
Jan 22, 2011·Genetika·P B Singh
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Jun 12, 2012·Genome Research·Andrea SmallwoodBing Ren
Jan 15, 2013·Biochemical and Biophysical Research Communications·Kumi MorikawaYasuaki Shirayoshi
Mar 29, 2013·Journal of Molecular Endocrinology·Momoe ItsumiSeiji Naito
Apr 23, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Seon-Sook HanYeon-Mok Oh
Jul 2, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ji ZhouJun Yan
Dec 3, 2014·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hiroaki OshiroYukiko Gotoh
Sep 1, 2015·Nucleic Acids Research·Yuichi MishimaIsao Suetake
Dec 15, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Han-Yue OuYangMing Shi
May 10, 2016·Nature Reviews. Disease Primers·Josep M LlovetGregory Gores
Feb 9, 2017·Journal of Cell Science·Christopher BotLena Ström
Feb 9, 2017·Pharmacology & Therapeutics·Rinku Dutta, Ram I Mahato
Mar 9, 2017·Genes & Development·Chengyang HuangMichael Carey
Sep 8, 2017·Cell Death & Disease·Jia-Hong WangRong-Ping Guo
Nov 11, 2017·Asia-Pacific Journal of Clinical Oncology·Shih-Chieh ChangJiun-I Lai
Dec 2, 2017·Oncotarget·Yuan-Ke LiangDe Zeng
Apr 19, 2018·Epigenetics & Chromatin·Kyohei OyamaW Robb MacLellan
Apr 22, 2018·Biochemical and Biophysical Research Communications·Lian-Yu ChenZhen Chen
May 8, 2018·Experimental and Therapeutic Medicine·Huayong ZhangAnkui Yang
Jun 16, 2018·International Journal of Molecular Sciences·Lian-Yu ChenZhen Chen
Aug 1, 2018·Nature Reviews. Clinical Oncology·Josep M LlovetRichard S Finn
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Mar 17, 2021·Nature Reviews. Molecular Cell Biology·Andrea Piunti, Ali Shilatifard
May 29, 2021·Frontiers in Oncology·Jian ZhouTang Liu
May 20, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Weifu ZhouFeng Liu

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
xenograft
electrophoresis

Software Mentioned

STRING
UALCAN
SPSS
TMAJ Image
GeneMANIA

Related Concepts

Related Feeds

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.