CC chemokine receptor 7 expression by effector/memory CD4+ T cells depends on antigen specificity and tissue localization during influenza A virus infection

Journal of Virology
Gudrun F DebesAlf Hamann

Abstract

The lung is an important entry site for respiratory pathogens such as influenza A virus. In order to combat such invading infectious agents, effector/memory T cells home to the lung and other peripheral tissues as well as lymphoid organs. In this process, chemokines and their receptors fulfill important roles in the guidance of T cells into such organs and specialized microenvironments within tissues. In this study, we determined if CD4(+) T cells residing in different lung compartments and draining lymph nodes of influenza A virus-infected and naïve mice express receptors allowing their recirculation into secondary lymphoid tissues. We found high levels of l-selectin and CC chemokine receptor 7 (CCR7) expression in lung-derived CD4(+) T cells, similar to that detected on T cells in secondary lymphoid organs. Upon influenza A virus infection, the bulk of gamma interferon-positive (IFN-gamma(+)) and IFN-gamma(-) CD4(+) T cells recovered from lung parenchyma retained functional CCR7, whereas virus-specific IFN-gamma-producing T cells were CCR7(-). In contrast, a majority of virus-specific IFN-gamma(+) T cells in the lung draining lymph node were CCR7(+). Independent of infection, CD4(+) T cells obtained from the lung airways exhi...Continue Reading

References

Jun 1, 1986·Immunological Reviews·S JalkanenE C Butcher
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P LaingC B Pert
Feb 1, 1995·American Journal of Respiratory and Critical Care Medicine·R Pabst, R M Binns
Mar 1, 1995·Infection and Immunity·D M Fernandes, C L Baldwin
Jan 7, 1998·Immunological Reviews·P C DohertyP G Stevenson
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·M D GunnL T Williams
Feb 10, 2000·Springer Seminars in Immunopathology·C Infante-Duarte, T Kamradt
Apr 27, 2000·Current Opinion in Immunology·J J Campbell, E C Butcher
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J J CampbellL Wu
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R J HoganD L Woodland
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M ItakuraK Matsushima
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J J CampbellA J Wardlaw
May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M E SewnathT van Der Poll
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·D D'AmbrosioF Sinigaglia
Nov 7, 2001·The Journal of Clinical Investigation·C H KimE C Butcher
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adrian W ZuercherJohn J Cebra
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gudrun F DebesAlf Hamann
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heike UnsoeldHanspeter Pircher
Oct 9, 2002·The Journal of Experimental Medicine·Eulogia RománSusan L Swain
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robert J HoganDavid L Woodland
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Frances E LundTroy D Randall
Nov 5, 2002·Journal of Virology·Gabrielle T BelzPeter C Doherty
Nov 20, 2002·The Journal of Clinical Investigation·Stephanie L ConstantKim Bottomly
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Linda S CauleyDavid L Woodland
Dec 12, 2003·Nature Reviews. Immunology·Ulrich H von Andrian, Thorsten R Mempel
Mar 6, 2004·Seminars in Immunology·Daniel J CampbellEugene C Butcher

❮ Previous
Next ❯

Citations

Nov 10, 2010·Immunology and Cell Biology·Cornelia DoebisUta Syrbe
Oct 29, 2013·Nature Immunology·Laura K MackayThomas Gebhardt
Aug 24, 2005·Nature Immunology·Gudrun F DebesEugene C Butcher
May 15, 2008·Viral Immunology·David VerhoevenDonna L Farber
Mar 16, 2005·Journal of Virology·Heike Unsoeld, Hanspeter Pircher
Oct 6, 2012·Trends in Immunology·Thomas GebhardtFrancis R Carbone
Aug 20, 2005·Immunology·Jens V Stein, César Nombela-Arrieta
Sep 14, 2007·Scandinavian Journal of Immunology·B BieleckiA Glabinski
Jun 20, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Li-Tao YangChang-You Wu
May 11, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Bartosz BieleckiAndrzej Glabinski
Jun 15, 2015·Trends in Immunology·Joseph J C Thome, Donna L Farber
May 29, 2012·Journal of Theoretical Biology·Gang HuangAndrei Korobeinikov
Nov 6, 2004·Seminars in Immunology·Tania S GourleyRafi Ahmed
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gudrun F DebesAlf Hamann
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Muriel StubbeArnaud Marchant
Oct 22, 2019·Frontiers in Cell and Developmental Biology·Yan YanQinxue Hu
Jan 6, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria M Steele, Amanda W Lund
Jul 5, 2021·Journal of Gastroenterology·Yan YanChantsalmaa Davgadorj
Oct 29, 2021·Immunological Reviews·Victor Collado-DiazCornelia Halin

❮ Previous
Next ❯

Related Concepts

Related Feeds