CCAAT/enhancer-binding protein beta mediates interferon-gamma-induced p48 (ISGF3-gamma ) gene transcription in human monocytic cells

The Journal of Biological Chemistry
W XiaoW Farrar

Abstract

Previous studies have identified a novel interferon-stimulated response element-like element, termed gamma-interferon-activating transcription element, within the interferon-stimulating gene factor-3gamma (p48) promoter region that is bound by novel transcription factors in response to stimulation with interferons (IFNs) (Weihua, X., Kolla, V., and Kalvakolanu, D. V. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 103-108). In the present study, we have identified CCAAT/enhancer-binding protein beta (C/EBP-beta) as one of the gamma-interferon-activating transcription element cognate transcription factors by screening a human monophage-derived cDNA library in a yeast one-hybrid system. Electrophoretic mobility shift assay studies suggest that C/EBP-beta dynamically regulates p48 gene expression upon IFN-gamma stimulation by undergoing changes in its heterodimerization partners. Transient transfection studies demonstrate that overexpression of C/EBP-beta strongly enhanced IFN-gamma-induced transcription from the p48 promoter. However, deletion mutants of C/EBP-beta that lack the N-terminal transactivation domain were unable to stimulate the p48 promoter. Western blotting revealed that C/EBP-beta is induced by IFN-gamma stimulation in ...Continue Reading

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Citations

Oct 11, 2003·Pharmacology & Therapeutics·Dhananjaya V Kalvakolanu
Aug 2, 2002·Biochimica Et Biophysica Acta·Yingmei YangMinou Bina
Dec 27, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Dhananjaya V Kalvakolanu, Sanjit K Roy
Dec 30, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M R Sandhya RaniRichard M Ransohoff
Feb 6, 2008·Molecular and Cellular Biology·Padmaja GadeDhananjaya V Kalvakolanu
Jun 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sanjit K RoyDhananjaya V Kalvakolanu
Aug 7, 2013·Developmental and Comparative Immunology·Jun ShiJian-Fang Gui
Sep 13, 2002·American Journal of Physiology. Cell Physiology·Blase BillackJeffrey D Laskin
Jun 7, 2002·The Journal of Biological Chemistry·Junbo HuDhananjaya V Kalvakolanu

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