CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control

Journal of Cellular Biochemistry
G S SivkoJames W Dewille

Abstract

CCAAT/enhancer binding protein delta (C/EBPdelta) plays a key role in mammary epithelial cell G0 growth arrest. C/EBPdelta gene expression is down-regulated in rodent mammary tumorigenesis and in human breast cancer, suggesting that "loss of function" alterations in C/EBPdelta gene expression are common in mammary gland malignancies. The goal of this study was to systematically investigate the mechanisms controlling C/EBPdelta gene expression in MCF-10A and MCF-12A human mammary epithelial cell lines. The results demonstrate that G0 growth arrest conditions (i.e., serum and growth factor withdrawal or Oncostatin M (OSM) treatment) result in the activation of JAK1, JAK2, and Tyk 2, members of the Janus kinase family of non-receptor tyrosine kinases, in MCF-10A and MCF-12A cells. Growth arrest or OSM treatment also specifically increases activated (phosphorylated) signal transduction and activators of transcription 3 (STAT3) levels, demonstrating that STAT3, not STAT1 or STAT5, is the downstream target of the activated Janus kinases in MCF-10A and MCF-12A cells. Whole cell lysates from G0 growth arrested (GA) and OSM-treated MCF-12A cells exhibit increased acute phase response element (APRE) binding compared to lysates from growi...Continue Reading

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Citations

Mar 29, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Bradley A Buckley
Apr 29, 2006·Journal of Cellular Physiology·Wei WeiPer-Olof Hasselgren
Oct 3, 2007·Journal of Cellular Biochemistry·Naomie TurgeonClaude Asselin
Feb 12, 2005·The Journal of Biological Chemistry·Marcella DebiddaYi Zheng
Apr 26, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ippei KuwaharaK Chul Kim
Sep 29, 2012·Biochemical Pharmacology·Carlota OleagaCarlos J Ciudad
Jul 29, 2021·American Journal of Physiology. Cell Physiology·Yoshitaka KubotaNobuyuki Mitsukawa

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