CCAAT/enhancer binding protein β is dispensable for development of lung adenocarcinoma

PloS One
Yi CaiSusumu Kobayashi

Abstract

Lung cancer is the leading cause of cancer death worldwide. Although disruption of normal proliferation and differentiation is a vital component of tumorigenesis, the mechanisms of this process in lung cancer are still unclear. A transcription factor, C/EBPβ is a critical regulator of proliferation and/or differentiation in multiple tissues. In lung, C/EBPβ is expressed in alveolar pneumocytes and bronchial epithelial cells; however, its roles on normal lung homeostasis and lung cancer development have not been well described. Here we investigated whether C/EBPβ is required for normal lung development and whether its aberrant expression and/or activity contribute to lung tumorigenesis. We showed that C/EBPβ was expressed in both human normal pneumocytes and lung adenocarcinoma cell lines. We found that overall lung architecture was maintained in Cebpb knockout mice. Neither overexpression of nuclear C/EBPβ nor suppression of CEBPB expression had significant effects on cell proliferation. C/EBPβ expression and activity remained unchanged upon EGF stimulation. Furthermore, deletion of Cebpb had no impact on lung tumor burden in a lung specific, conditional mutant EGFR lung cancer mouse model. Analyses of data from The Cancer Geno...Continue Reading

References

Jul 1, 1981·AJR. American Journal of Roentgenology·R M LevensonJ D Minna
Jul 1, 1995·Immunobiology·A Wedel, H W Ziegler-Heitbrock
Oct 24, 1998·The Journal of Biological Chemistry·J Lekstrom-Himes, K G Xanthopoulos
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B L Burgess-BeusseG J Darlington
Sep 19, 2000·Acta Obstetricia Et Gynecologica Scandinavica·K IvarssonM Brännström
Apr 12, 2002·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Robert J Cersosimo
Sep 18, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Chikako KiyoharaJulian M Hopkin
Oct 3, 2002·Nature Reviews. Cancer·James E Darnell
Dec 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Qi-Qun TangM Daniel Lane
Sep 10, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tobias N Cassel, Magnus Nord
Sep 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Huajing WanJeffrey A Whitsett
Feb 10, 2006·Development·Prithy C MartisMachiko Ikegami
Mar 16, 2006·Journal of the National Cancer Institute·Yasuhiro TadaChristoph Plass
Jun 6, 2006·Nature Immunology·Hideyo HiraiDaniel G Tenen
Jun 13, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Daniel B CostaBalazs Halmos
Jan 24, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Daniel B CostaBalazs Halmos
Dec 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steffen KoschmiederDaniel G Tenen
Jul 16, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Zdenko Herceg, Thomas Vaissière
Nov 8, 2011·Clinics in Chest Medicine·Charles S Dela CruzRichard A Matthay
Mar 14, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Abraham B RoosMagnus Nord
May 2, 2012·Cancer Letters·Triantafillos LiloglouMichael P A Davies
Sep 21, 2013·Current Opinion in Oncology·Jennifer E YehDavid A Frank
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Mar 19, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Aug 8, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hélène Dubois-Pot-SchneiderAnne Corlu
Aug 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tomomi TadokoroBrigid L M Hogan
Aug 29, 2014·Cancer Research·Sohei NakayamaSusumu S Kobayashi

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Citations

Sep 29, 2020·Frontiers in Oncology·Toshihide NishimuraHisashi Saji

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Methods Mentioned

BETA
genotyping
electrophoresis
Assay
nuclear translocation
transgenic

Software Mentioned

ImageQuant

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