PMID: 8971924Jan 1, 1996Paper

CCK-58: a novel reagent for studying the regulation of cholecystokinin bioactivity

Peptides
H E Raybould, Joseph R Reeve

Abstract

CCK-58 has been shown to be the major circulating form of the hormone in the dog and human. To date, there have been no reports on its biological activity in vivo. We report here that CCK-8 and CCK-58 were equipotent in decreasing gastric motor function after bolus doses and in stimulating protein secretion after continuous infusion in urethane-anesthetized rats. The present results are the first on the in vivo activity of CCK-58, and indicate that because CCK-58 is equipotent to CCK-8, and because it is a major released and circulating form, it may be considered as a major contributor to the expression of cholecystokinin bioactivity.

References

Sep 1, 1990·Gastroenterology·C M TurkelsonT E Solomon
Nov 1, 1988·Peptides·C M TurkelsonJ R Reeve
Jan 1, 1980·Annual Review of Biophysics and Bioengineering·R S Yalow
Oct 1, 1995·Cellular and Molecular Neurobiology·P BodenJ Hughes

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Citations

May 31, 2008·Nutritional Neuroscience·Joerg GlatzleTilman T Zittel
Dec 22, 1999·Biochemical and Biophysical Research Communications·D A KeireJ R Reeve
Jul 29, 2008·Brain Research Reviews·Daniela M Sartor, Anthony J M Verberne
Nov 8, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Joseph R ReeveTamer Coskun
Apr 6, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Joseph R ReeveTamer Coskun
Mar 20, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·M NakajimaT Hayakawa
Dec 1, 2018·Metabolism: Clinical and Experimental·Didier Chapelot, Keyne Charlot

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