CCK-8S facilitates 5-HT release in the rat hypothalamus

Pharmacology, Biochemistry, and Behavior
J P VoigtH Fink

Abstract

The effects of the neurotransmitter serotonin (5-HT) and the neuropeptide cholecystokinin (CCK) on food intake are well established. Based on pharmacological studies, an interactive model for 5-HT and CCK was proposed. The present microdialysis study was aimed to provide neurochemical evidence for a facilitatory effect of CCK-8S on 5-HT release in the lateral hypothalamus under in vivo conditions. The results indicate an increase of extracellular hypothalamic 5-HT both during food intake in previously food-deprived rats and also after systemic administration of 8 microg/kg and 40 microg/kg CCK-8s in food-deprived rats. The results show that peripherally administered CCK-8s induces central serotonergic effects, possibly related to feeding.

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Citations

Sep 25, 1999·European Journal of Pharmacology·U ZippelH Davidowa
Jan 19, 2000·Pharmacology, Biochemistry, and Behavior·J P VoigtH Fink
Jul 23, 2003·Regulatory Peptides·Mônica Marques TellesEliane Beraldi Ribeiro
Feb 28, 2001·Diabetes, Obesity & Metabolism·B BaranowskaM Borowiec
Nov 9, 2005·The Japanese Journal of Physiology·Kyoko MiyasakaAkihiro Funakoshi
May 10, 2011·Physiology & Behavior·Luis HernándezPedro Rada
Jul 23, 2008·Developmental Disabilities Research Reviews·Jason C G Halford, Joanne A Harrold
Sep 15, 2014·Behavioural Brain Research·Jörg-Peter Voigt, Heidrun Fink
Feb 12, 2017·Journal of Biochemical and Molecular Toxicology·Tongtong GeRanji Cui
May 23, 2000·Annals of Medicine·J C Halford, J E Blundell
Oct 27, 1999·Canadian Journal of Physiology and Pharmacology·R C MoriE B Ribeiro
Aug 15, 2002·The Journal of Surgical Research·Tilman T ZittelEkkehard C Jehle
Sep 7, 2021·Physiological Reviews·Alan G WattsWolfgang Langhans

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