PMID: 8447480Feb 1, 1993Paper

CCK satiety is differentially mediated by high- and low-affinity CCK receptors in mice and rats

The American Journal of Physiology
S C WeatherfordT H Moran

Abstract

Cholecystokinin-JMV-180 (JMV-180) is an analogue of cholecystokinin C-terminal octapeptide (CCK-8), which has been shown to be an agonist at the proposed CCK pancreatic high-affinity site and a functional antagonist at the pancreatic low-affinity site in rats and to have agonist activity at both high- and low-affinity sites in the mouse. In this study we used JMV-180 to evaluate the potential participation of these two CCK-A sites in the satiety effect of CCK-8 in rats and mice. When tested at doses that ranged from 0.01 to 9.2 mumol/kg, JMV-180 did not reliably affect food intake of solid or liquid test diets in rats. When combined with CCK-8 (3.2 or 8.5 nmol/kg) JMV-180 dose dependently reversed the satiety effect of CCK-8. In contrast to these results in the rat, both JMV-180 (3.7-14.8 mumol/kg) and CCK-8 (1.7-6.8 nmol/kg) dose dependently reduced the intake of 20% sucrose in mice. Both CCK-8- and JMV-180-induced suppression of food intake were attenuated by the CCK-A antagonist MK-329 (24.8 nmol/kg). The results of these studies suggest that agonist activity at sites pharmacologically similar to the CCK pancreatic high-affinity site is not sufficient for expression of CCK satiety, whereas agonist activity at low-affinity-li...Continue Reading

Citations

Aug 10, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Miriam Goebel-StengelJoseph R Reeve
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Steven M SimaskoRobert C Ritter
Jan 13, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Timothy H Moran, Kimberly P Kinzig
Sep 1, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Andrea HeldsingerChung Owyang
Feb 20, 2020·American Journal of Physiology. Cell Physiology·Cody W KowalskiJames H Peters
Oct 26, 2005·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·T J LittleC Feinle-Bisset
May 23, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tim O LankischChung Owyang
Nov 27, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ying LiChung Owyang
Aug 30, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Steven M Simasko, Robert C Ritter
Jun 22, 2021·Frontiers in Endocrinology·Laurence J MillerPatrick M Sexton

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