CCL17 and CCL22/CCR4 signaling is a strong candidate for novel targeted therapy against nasal natural killer/T-cell lymphoma

Cancer Immunology, Immunotherapy : CII
Takumi KumaiYasuaki Harabuchi

Abstract

Nasal natural killer/T-cell lymphoma (NNKTL) is associated with Epstein-Barr virus and has a poor prognosis because of local invasion and/or multiple dissemination. Various chemokines play a role in tumor proliferation and invasion, and chemokine receptors including the C-C chemokine receptor 4 (CCR4) are recognized as potential targets for treating hematologic malignancies. The aim of the present study was to determine whether specific chemokines are produced by NNKTL. We compared chemokine expression patterns in culture supernatants of NNKTL cell lines with those of other lymphoma or leukemia cell lines using chemokine protein array and ELISA. Chemokine (C-C motif) ligand (CCL) 17 and CCL22 were highly produced by NNKTL cell lines as compared to the other cell lines. In addition, CCL17 and CCL22 were readily observed in the sera of NNKTL patients. The levels of these chemokines were significantly higher in patients than in healthy controls. Furthermore, we detected the expression of CCR4 (the receptor for CCL17 and CCL22) on the surface of NNKTL cell lines and in tissues of NNKTL patients. Anti-CCR4 monoclonal antibody (mAb) efficiently induced antibody-dependent cellular cytotoxicity mediated by natural killer cells against ...Continue Reading

References

Dec 5, 1998·Journal of Immunological Methods·J M WangS Su
Jun 25, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E MaggioS Poppema
Jun 15, 1980·International Journal of Cancer. Journal International Du Cancer·Z RavidM Greaves
Mar 5, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tomás AlvaroMiguel A Piris
Dec 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Toshihiro NagatoYasuaki Harabuchi
Jan 18, 2006·British Journal of Haematology·Arian D J Laurence
Sep 6, 2006·Cancer Science·Takashi Ishida, Ryuzo Ueda
Oct 3, 2006·International Journal of Cancer. Journal International Du Cancer·Miki TakaharaEva Klein
Feb 16, 2008·British Journal of Haematology·Marijke NiensAnke van den Berg
Nov 18, 2008·Seminars in Cancer Biology·J M Middeldorp, D M Pegtel
Jul 14, 2009·International Journal of Clinical Oncology·Yasuaki HarabuchiHideyuki Ishii
Sep 15, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Asahi ItoRyuzo Ueda
Nov 6, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shigetaka MoriaiYasuaki Harabuchi
Feb 18, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Toshihiko IshiiRyuzo Ueda
Feb 24, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kazuhito YamamotoRyuzo Ueda
Nov 22, 2013·Oncotarget·Purvaba J SarvaiyaMaciej S Lesniak
Aug 15, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tetsuhiro KanazawaHiroshi Kimura

❮ Previous
Next ❯

Citations

Dec 8, 2015·Immunotherapy·Takumi KumaiYasuaki Harabuchi
Jan 22, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Toshihiro NagatoYasuaki Harabuchi
Apr 7, 2020·Expert Opinion on Therapeutic Targets·Valentin BalochePierre Busson
Aug 25, 2018·Oncotarget·Kashif RasheedUgo Moens
Jul 29, 2020·Blood Research·Seong Hyun Jeong
May 2, 2019·Frontiers in Pediatrics·Yasuaki HarabuchiTakumi Kumai
Feb 6, 2020·Frontiers in Neurology·Sarah R MarthaKeith R Pennypacker
Aug 3, 2021·Allergology International : Official Journal of the Japanese Society of Allergology·Masaki YamadaKen-Ichi Imadome
Jul 2, 2019·Journal of Medicinal Chemistry·Jeffrey J JacksonMikhail Zibinsky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Shigetaka MoriaiYasuaki Harabuchi
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Toshihiko IshiiRyuzo Ueda
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Tetsuhiro KanazawaHiroshi Kimura
© 2022 Meta ULC. All rights reserved