CCL2 gene polymorphism is associated with post-transplant diabetes mellitus

International Immunopharmacology
Ewa Dabrowska-ZamojcinAndrzej Pawlik

Abstract

Post-transplant diabetes mellitus (PTDM) is a common complication after solid organ transplantation, especially in recipients treated with calcineurin inhibitors. Previous studies suggest that chronic inflammation and chemokines play an important role in the pathogenesis of diabetes. Single-nucleotide polymorphisms (SNPs) can increase or decrease transcriptional activity and can change the production of chemokines. The aim of this study was to examine the association between CCL2 and CCL5 gene polymorphisms and the development of post-transplant diabetes mellitus. The study included 315 patients who received kidney transplants and were treated with calcineurin inhibitors. Patients were divided into two subgroups: with PTDM (n=43) and without PTDM (n=272). An additive model of univariate Cox regression analysis showed that the hazard of PTDM development was significantly positively associated with the number of CCL2 rs1024611 G alleles (HR 1.65; 95%CI 1.08-2.53; p=0.021). Multivariate Cox regression analysis, taking into the account the recipient's sex, age and BMI, as well as the number of G alleles of the CCL2 rs1024611 polymorphism, revealed that this polymorphism is an independent risk factor for post-transplant diabetes. Th...Continue Reading

References

Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·H LiuT Shioda
Jun 11, 1999·Biochemical and Biophysical Research Communications·B H RovinR Saxena
Jun 14, 2001·Lancet·M FischerederD Schlöndorff
Sep 18, 2002·Kidney International·Fernando G CosioRonald M Ferguson
Dec 31, 2002·Journal of Diabetes and Its Complications·Tsukasa MoriiSeiki Ito
May 22, 2003·Metabolism: Clinical and Experimental·Jøran HjelmesaethAnders Hartmann
Jun 25, 2004·The American Journal of Pathology·Kiyoki KitagawaHitoshi Yokoyama
Aug 18, 2004·Neurobiology of Aging·Chiara FenoglioElio Scarpini
Oct 14, 2011·Diabetes Research and Clinical Practice·Yonggang ZhangJin Huang
Dec 13, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Pramod NagarajaKesh Baboolal
Jun 29, 2013·Diabetes & Metabolism Journal·Tsuguhito Ota
Dec 7, 2013·Journal of the American Society of Nephrology : JASN·Jennifer A McCaughanAlexander P Maxwell
Mar 25, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Luigi Gnudi

❮ Previous
Next ❯

Citations

Jun 3, 2018·Archives of Pharmacal Research·Mou-Ze LiuWei Zhang
Apr 4, 2021·International Journal of Molecular Sciences·Jacek RyszAnna Gluba-Brzózka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.