CCL3/MIP-1alpha is pro-inflammatory in murine T cell-mediated hepatitis by recruiting CCR1-expressing CD4(+) T cells to the liver

European Journal of Immunology
Maureen N AjueborMark G Swain

Abstract

T cell-mediated hepatitis is associated with significant morbidity and mortality worldwide. Levels of C-C chemokine ligand 3/macrophage inflammatory protein-1alpha (CCL3/MIP-1alpha) are elevated in the serum of patients with T cell-mediated liver diseases, but its role is not fully understood. Con A-induced hepatitis is a murine liver-specific inflammation mediated by activated T cells and is driven by an up-regulation of the hepatic expression of IFN-gamma. In this study, we have used CCL3/MIP-1alpha gene-deficient mice to examine the role of CCL3/MIP-1alpha in the pathogenesis of Con A-induced hepatitis. We demonstrate a novel pro-inflammatory role for CCL3/MIP-1alpha since CCL3/MIP-1alpha deficiency significantly attenuated hepatic injury, both biochemically and histologically. Moreover, the recruitment of CCR1-expressing CD4(+) T cells to the liver after Con A treatment was strikingly attenuated by CCL3/MIP-1alpha deficiency. Correspondingly, hepatic IFN-gamma produced by the recruited CD4(+) T cells was significantly reduced by CCL3/MIP-1alpha deficiency during Con A-induced hepatitis. Furthermore, treatment of mice with a dual CCR1/CCR5 peptide antagonist, methionylated RANTES, also markedly reduced hepatic injury and dec...Continue Reading

Citations

Aug 10, 2010·European Journal of Clinical Pharmacology·Hugh G LavertyB Kevin Park
Oct 27, 2010·Nature Reviews. Gastroenterology & Hepatology·Hacer SahinHermann E Wasmuth
May 13, 2010·Digestive Diseases·Ye H OoDavid H Adams
Oct 28, 2010·The Journal of Clinical Investigation·Marie-Luise BerresHermann E Wasmuth
Jun 27, 2013·PloS One·Daniel HeinrichsHacer Sahin
Aug 1, 2013·World Journal of Gastroenterology : WJG·Priscila Menezes Ferri LiuAna Cristina Simões e Silva
Oct 30, 2013·Immunology and Cell Biology·Hao LiuDmitry I Gabrilovich
Mar 22, 2014·International Journal of Molecular Sciences·Anette Brass, Erwin Daniel Brenndörfer
Dec 6, 2005·Pediatric Surgery International·Johannes LeonhardtClaus Petersen
Feb 12, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Midori KojimaHiroyuki Eda
Jan 31, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Carmen BotellaManuel Muro
Feb 9, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Hao YinCynthia Ju
Sep 1, 2004·European Journal of Pharmacology·Maureen N AjueborCory M Hogaboam
May 17, 2005·Cellular Immunology·Sachiyo HatadaYoshiro Kobayashi
Sep 19, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Israa G AkramMartin R Berger
Feb 3, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nirupma TrehanPatiShiv Kumar Sarin
Nov 13, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Dechun FengLingyun Xu
Jan 14, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tania Santodomingo-GarzonMark G Swain
Jan 30, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mathis Heydtmann, David H Adams
Dec 30, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard G RuddellGrant A Ramm
Oct 27, 2011·Yonsei Medical Journal·Wonseok Kang, Eui-Cheol Shin
Jul 19, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Feng ZhouMark G Swain
Sep 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christophe MorenoHubert Louis
Nov 26, 2011·Expert Review of Clinical Pharmacology·Hacer SahinHermann E Wasmuth
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maureen N AjueborMark G Swain
Aug 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maureen N AjueborMark G Swain
Dec 17, 2008·Expert Review of Gastroenterology & Hepatology·Karlin Raja KarlmarkFrank Tacke
Sep 29, 2020·Frontiers in Physiology·Alex L WilkinsonShishir Shetty
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christina A BursillDavid R Greaves
Feb 9, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Junji YamashitaToshinori Nakayama
Dec 25, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexandre BignonKarl Balabanian
May 15, 2015·The Journal of Toxicological Sciences·Shima GotoHitoshi Funabashi
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elena CitteraJosée Golay
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chi-Hsun HsiehIrshad H Chaudry

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