Abstract
Chemokines/cytokines play important roles in the pathogenesis of chronic hepatitis C (CHC). However, their clinical characteristics and implications in treatment responses to pegylated interferon plus ribavirin treatment (PegIFN/RBV) have not been fully illustrated yet. In this study, we intended to investigate the possible predictability of serum chemokines/cytokines on the treatment response in Taiwanese of CHC, genotype-1 (GT-1). 60 Patients with GT-1 CHC infection who had been treated with PegIFN/RBV were enrolled, including 27 (45%) with sustained virological response (SVR), 11 (18%) with relapse after 48 weeks of treatment and 22 (37%) non-response (NR). Clinical parameters, seven chemokines/cytokines, CCL3, CCL4, CXCL9, CXCL10, CXCL11, IL-10 and IFN-γ, and genotypes of rs12979860, the single nucleotide polymorphisms (SNPs) of interleukin-28B (IL28B) were analyzed for their relationship to treatment response. Baseline serum levels of CXCL10, CXCL11, CCL3 and CCL4 were significantly higher in NR group while comparing with non-NR group. (CXCL10: p = 0.001; CXCL11: p < 0.001; CCL3: p = 0.006; CCL4: p = 0.005). However, only rs12979860 CC genotype was the independent factors for NR in GT-1 CHC infection (OR, 8.985; p = 0.008)...Continue Reading
References
Jul 7, 2001·The New England Journal of Medicine·G M Lauer, B D Walker
Nov 12, 2002·The American Journal of Gastroenterology·Arantxa ApolinarioCarmelo García-Monzón
Dec 31, 2003·Lancet·Thierry PoynardChing Lung Lai
Feb 28, 2004·Alimentary Pharmacology & Therapeutics·A ApolinarioC García-Monzón
Apr 30, 2005·Blood·David ButeraLynn B Dustin
Sep 10, 2005·Gut·M DiagoC García-Monzón
Feb 10, 2006·The New England Journal of Medicine·Israel F Charo, Richard M Ransohoff
Jun 15, 2007·Journal of Hepatology·Juan-Ramón LarrubiaTrinidad Parra
Jul 17, 2007·Cytokine·Ori WaldAmnon Peled
Nov 21, 2007·Journal of Viral Hepatitis·E Jenny Heathcote
Dec 17, 2008·World Journal of Gastroenterology : WJG·Juan R LarrubiaTrinidad Parra-Cid
Apr 2, 2009·Journal of Gastroenterology and Hepatology·Ming-Lung Yu, Wan-Long Chuang
Aug 18, 2009·Nature·Dongliang GeDavid B Goldstein
Sep 15, 2009·Nature Genetics·Yasuhito TanakaMasashi Mizokami
Dec 17, 2009·Gut·Alessandra Mangia, Angelo Andriulli
Mar 12, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J FlorholmenR Goll
Jul 20, 2010·Gastroenterology·Mark G SwainMoisés Diago
Jul 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul J PockrosAnna S Lok
Nov 30, 2010·Gastroenterology·Michael T DillMarkus H Heim
Jan 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Tarik Asselah, Patrick Marcellin
Apr 12, 2011·PloS One·Chun-Yen LinI-Shyan Sheen
Dec 12, 2013·Journal of Gastroenterology and Hepatology·Kentaro MatsuuraYasuhito Tanaka
Aug 29, 2014·Therapeutic Advances in Infectious Disease·Astrid Wendt, Marc Bourlière
Dec 3, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Shibin ZhangXinyue Chen
Jun 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·UNKNOWN AASLD/IDSA HCV Guidance Panel
Jan 5, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Tarik AsselahPatrick Marcellin