CCL8 and the Immune Control of Cytomegalovirus in Organ Transplant Recipients

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Luiz F LisboaAtul Humar

Abstract

Monitoring of cytomegalovirus cell-mediated immunity is a promising tool for the refinement of preventative and therapeutic strategies posttransplantation. Typically, the interferon-γ response to T cell stimulation is measured. We evaluated a broad range of cytokine and chemokines to better characterize the ex vivo host-response to CMV peptide stimulation. In a cohort of CMV viremic organ transplant recipients, chemokine expression-specifically CCL8 (AUC 0.849 95% CI 0.721-0.978; p = 0.003) and CXCL10 (AUC 0.841, 95% CI 0.707-0.974; p = 0.004)-was associated with control of viral replication. In a second cohort of transplant recipients at high-risk for CMV, the presence of a polymorphism in the CCL8 promoter conferred an increased risk of viral replication after discontinuation of antiviral prophylaxis (logrank hazard ratio 3.6; 95% CI 2.077-51.88). Using cell-sorting experiments, we determined that the primary cell type producing CCL8 in response to CMV peptide stimulation was the monocyte fraction. Finally, in vitro experiments using standard immunosuppressive agents demonstrated a dose-dependent reduction in CCL8 production. Chemokines appear to be important elements of the cell-mediated response to CMV infection posttranspl...Continue Reading

References

Jun 11, 1998·The Journal of Biological Chemistry·S HashemolhosseiniS Ferrari
Mar 29, 2001·Nature Immunology·S A Luther, J G Cyster
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H T MaeckerV C Maino
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark R WillsAndrew J Carmichael
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroko TomiyamaMasafumi Takiguchi
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kirsten L HokenessThais P Salazar-Mather
Jun 22, 2005·International Journal of Medical Informatics·Alexander StatnikovConstantin F Aliferis
Dec 28, 2005·Journal of Virology·R Travis Taylor, Wade A Bresnahan
Jul 31, 2007·Nature Immunology·Stéphanie HuguesLuc Fetler
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tao WangZhenhua Dai
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Annabel F ValledorAntonio Celada
Aug 12, 2008·International Immunopharmacology·Mari HämäläinenEeva Moilanen
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christoph HintzenHeike M Hermanns
May 9, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D KumarA Humar
Aug 12, 2009·Neuroscience Letters·Masaaki NiinoHidenao Sasaki
Oct 29, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hongwei H ZhangJoshua M Farber
Nov 9, 2010·Vaccine·Pier Adelchi RuffiniBjarne Bogen
Jan 12, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L WeseslindtnerE Puchhammer-Stöckl
Apr 26, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hongxia MaHongbing Shen
Aug 5, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J A JacksonA D Kirk
Nov 2, 2011·The Journal of Experimental Medicine·Heather D HickmanJonathan W Yewdell
Feb 22, 2012·Nature Reviews. Immunology·Holden T MaeckerRobert Nussenblatt
Jul 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Gavin M MasonJohn H Sinclair
Sep 20, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adrian EgliDeepali Kumar
Nov 7, 2012·Nature·UNKNOWN 1000 Genomes Project ConsortiumGil A McVean
Dec 1, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Oriol ManuelAtul Humar
Jan 15, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S CantisánJ Torre-Cisneros
May 28, 2013·Cell Reports·Hirotaka NakahashiRafael Casellas
Jul 17, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kai HuQinxue Hu
Sep 17, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C MacedoD Metes

❮ Previous
Next ❯

Citations

Mar 30, 2018·Transplantation·Camille N KottonUNKNOWN The Transplantation Society International CMV Consensus Group
Dec 29, 2017·BMC Immunology·Baosheng GeNaseer Ullah Khan
Jan 26, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Lukas WeseslindtnerKlaus Hedman
Mar 13, 2018·The Journal of Clinical Investigation·Kang YuDeborah N Burshtyn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

© 2021 Meta ULC. All rights reserved