CCN3 increases cell motility and ICAM-1 expression in prostate cancer cells

Carcinogenesis
Po-Chun ChenChih-Hsin Tang

Abstract

Nephroblastoma overexpressed (NOV or CCN3) is a secreted matrix-associated protein that belongs to the CCN gene family and is involved in many cellular functions, including growth, differentiation and adhesion. The effect of CCN3 on human prostate cancer cells, however, is unknown. Here, we have shown that CCN3 increased cell migration and intercellular adhesion molecule-1 (ICAM-1) expression in prostate cancer cells. In addition, expression of CCN3 was positively correlated with both cell migration and ICAM-1 expression in human prostate cancer cells. CCN3 activated a signal transduction pathway that included αvβ3 integrin, integrin-linked kinase (ILK), Akt and nuclear factor-kappaB (NF-κB). Reagents that inhibit specific components of this pathway each diminished the ability of CCN3 to effect cell migration and ICAM-1 expression. Moreover, CCN3 increased binding of p65 to an NF-κB-binding element in the ICAM-1 promoter. Finally, knockdown of CCN3 expression markedly inhibited cell migration, tumor growth in bone and bone metastasis. Taken together, our results indicate that CCN3 enhances the migration of prostate cancer cells by increasing ICAM-1 expression through a signal transduction pathway that involves αvβ3 integrin, IL...Continue Reading

References

Jan 1, 1996·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·A van de Stolpe, P T van der Saag
Jul 17, 1999·Trends in Cell Biology·S DedharG Hannigan
Aug 3, 2002·Nature Reviews. Cancer·Gregory R Mundy
Apr 16, 2003·The Journal of Biological Chemistry·Cristiane G LinLester F Lau
Sep 3, 2003·The Journal of Biological Chemistry·Huey-Chun HuangHua-Lin Wu
Sep 13, 2003·Cancer Cell International·Nathalie Planque, Bernard Perbal
Jan 16, 2004·Lancet·Bernard Perbal
Apr 15, 2004·Endocrine Reviews·Cynthia A Heinlein, Chawnshang Chang
Dec 22, 2004·The Journal of Biological Chemistry·Cristiane G LinLester F Lau
Mar 19, 2005·Carcinogenesis·Caridad RosetteMikhail F Denissenko
Dec 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yi-Chu LinChing-Chow Chen
Feb 3, 2007·Cancer Science·Jun-Ichiro InoueKentaro Semba
Feb 15, 2007·Journal of Cellular Physiology·Chih-Chung LinChuen-Mao Yang
Jun 7, 2007·Molecular Pharmacology·Yung-Cheng ChiuChih-Hsin Tang
Sep 11, 2007·European Urology·Richard J Bryant, Freddie C Hamdy
Oct 2, 2007·European Journal of Pharmacology·Bernhard H RauchKarsten Schrör
Feb 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bernard PerbalKatia Scotlandi
Aug 30, 2008·Blood Reviews·L McCallum, A E Irvine
Sep 9, 2008·The International Journal of Biochemistry & Cell Biology·Chih-Chiun Chen, Lester F Lau
Sep 11, 2008·Current Pharmaceutical Design·Tahl Zimmerman, Francisco J Blanco
Mar 25, 2009·Pharmacological Reports : PR·Charlotte Lawson, Sabine Wolf
Aug 22, 2009·Human Pathology·Bernard PerbalPiero Picci
Nov 17, 2009·Cancer Investigation·Nektaria MakriliaKostas Syrigos

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Citations

Jan 1, 2013·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Claire LugassyRaymond L Barnhill
Feb 20, 2014·BioMed Research International·Po-Chun ChenChih-Hsin Tang
Feb 13, 2016·Scientific Reports·S KleeM Königshoff
Jan 26, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Timothy N Trotter, Yang Yang
Sep 4, 2012·Cancer Letters·Yu-Min LinChih-Hsin Tang
Jun 25, 2013·Pigment Cell & Melanoma Research·Claire LugassyRaymond L Barnhill
Aug 2, 2015·Clinical & Experimental Metastasis·Fabiola CecchiDonald P Bottaro
Jul 21, 2015·Archives of Oral Biology·Negar HomayounfarMichael L Cunningham
Aug 16, 2016·Journal of Cell Communication and Signaling·Herman Yeger, Bernard Perbal
Jun 28, 2013·International Journal of Molecular Sciences·Hsin-Shan YuChih-Hsin Tang
Mar 17, 2019·Cellular Oncology (Dordrecht)·Ahmad GhasemiSeyed Isaac Hashemy
Jun 27, 2020·Scientific Reports·Janaína M SilvaJuliana de S da G Fischer
Jun 17, 2019·The American Journal of Pathology·Matthew DanknerUNKNOWN Canadian Prostate Cancer Biomarker Network
Jun 3, 2021·Cancers·Nico Hinz, Manfred Jücker

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