CCN3 Regulates Macrophage Foam Cell Formation and Atherosclerosis

The American Journal of Pathology
Hong ShiZhiyong Lin

Abstract

Recent studies implicate the Cyr61, CTGF, Nov (CCN) matricellular signaling protein family as emerging players in vascular biology, with NOV (alias CCN3) as an important regulator of vascular homeostasis. Herein, we examined the role of CCN3 in the pathogenesis of atherosclerosis. In response to a 15-week high-fat diet feeding, CCN3-deficient mice on the atherosclerosis-prone Apoe-/- background developed increased aortic lipid-rich plaques compared to control Apoe-/- mice, a result that was observed in the absence of alterations in plasma lipid content. To address the cellular contributor(s) responsible for the atherosclerotic phenotype, we performed bone marrow transplantation experiments. Transplantation of Apoe; Ccn3 double-knockout bone marrow into Apoe-/- mice resulted in an increase of atherosclerotic plaque burden, whereas transplantation of Apoe-/- marrow to Apoe; Ccn3 double-knockout mice caused a reduction of atherosclerosis. These results indicate that CCN3 deficiency, specifically in the bone marrow, plays a major role in the development of atherosclerosis. Mechanistically, cell-based studies in isolated peritoneal macrophages demonstrated that CCN3 deficiency leads to an increase of lipid uptake and foam cell forma...Continue Reading

Citations

Dec 8, 2017·Journal of Cell Communication and Signaling·Wenconghui WuZhiyong Lin
Feb 8, 2018·Journal of Cell Communication and Signaling·Stephen M Twigg
Sep 7, 2017·GeroScience·Zoltan UngvariAnna Csiszar
Dec 17, 2018·Acta Physiologica·Andreas ZietzerFelix Jansen
Sep 27, 2019·Pharmacological Reviews·Dongdong WangAtanas G Atanasov
Nov 20, 2020·Cardiovascular Research·Hongyang ShuDao Wen Wang
Oct 15, 2020·Immunology Letters·Fengge WangYuekang Xu
Aug 17, 2021·Mediators of Inflammation·Linan PengLihua Duan

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