CCNE1 copy-number gain and overexpression identify ovarian clear cell carcinoma with a poor prognosis

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Ayse AyhanTian-Li Wang

Abstract

Ovarian clear cell carcinoma is a unique type of ovarian cancer, often derived from endometriosis, and advanced-stage disease has a dismal prognosis primarily due to the resistance to conventional chemotherapy. Previous studies have shown frequent somatic mutations in ARID1A, PIK3CA, hTERT promoter, and amplification of ZNF217; however, the molecular alterations that are associated with its aggressiveness remain largely unknown. This study examined and compared cyclin E1 expression in endometriosis-related ovarian tumors, with the aim of determining the relationship between hTERT mutations and ARID1A expression and evaluating the effects of these molecular alterations on patient survival. We performed immunohistochemistry on 207 tumors [clear cell carcinoma (n=120), endometrioid carcinoma (n=49), and seromucinous tumors (n=38)], followed by two-color fluorescence in situ hybridization (n=88) and compared with ARID1A expression and hTERT promoter mutations in the same samples. Cyclin E1 overexpression and CCNE1 copy-number gain occurred in 23.3% and 14.8% of ovarian clear cell carcinomas, respectively, but they were not detected in any of the other endometriosis-related tumors. All cases with CCNE1 copy-number gain demonstrated ...Continue Reading

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Citations

May 11, 2019·Expert Review of Molecular Diagnostics·Ben Davidson
Sep 4, 2019·Annual Review of Pathology·Yeh WangIe-Ming Shih
Dec 1, 2017·Journal of Clinical Pathology·Elisabetta Kuhn, Ayse Ayhan
Sep 29, 2020·Cancer Medicine·Anders BerglundJong Y Park
Jan 19, 2018·The Journal of Pathology·Jennifer X JiDavid G Huntsman
Apr 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia Magdalena ChrzanowskaMarzena Anna Lewandowska
Apr 10, 2021·Scientific Reports·Toshiyuki SekiAikou Okamoto
Jun 3, 2021·International Journal of Molecular Sciences·Naoki KawaharaHiroshi Kobayashi

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