CCR 20th anniversary commentary: BMS-247550—microtubule stabilization as successful targeted therapy

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Navjotsingh Pabla, Alex Sparreboom

Abstract

In a landmark article published in the May 1, 2001, issue of Clinical Cancer Research, Lee and colleagues reported the original preclinical studies demonstrating anticancer activity of BMS-247550 (ixabepilone) against taxane-sensitive and taxane-resistant cancers. Subsequent clinical trials established the clinical efficacy of ixabepilone, leading to its regulatory approval for the treatment of drug-resistant metastatic or locally advanced breast cancers.

References

Jul 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert J LechleiderRichard Pazdur
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Antoinette R Tan, Deborah L Toppmeyer
Jan 29, 2009·Molecular Cancer Therapeutics·John T Hunt
Mar 8, 2013·Future Medicinal Chemistry·Jenny Seligmann, Chris Twelves
Jan 9, 2014·Anti-cancer Drugs·Cynthia F BrogdonRenzo M Canetta
Apr 24, 2014·Cancer Research·Annemieke J M NieuweboerAlex Sparreboom

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