CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair.

Blood
Sebastian WillenborgSabine A Eming

Abstract

Monocytes/macrophages are critical in orchestrating the tissue-repair response. However, the mechanisms that govern macrophage regenerative activities during the sequential phases of repair are largely unknown. In the present study, we examined the dynamics and functions of diverse monocyte/macrophage phenotypes during the sequential stages of skin repair. By combining the analysis of a new CCR2-eGFP reporter mouse model with conditional mouse mutants defective in myeloid cell-restricted CCR2 signaling or VEGF-A synthesis, we show herein that among the large number of inflammatory CCR2(+)Ly6C(+) macrophages that dominate the early stage of repair, only a small fraction strongly expresses VEGF-A that has nonredundant functions for the induction of vascular sprouts. The switch of macrophage-derived VEGF-A during the early stage of tissue growth toward epidermal-derived VEGF-A during the late stage of tissue maturation was critical to achieving physiologic tissue vascularization and healing progression. The results of the present study provide new mechanistic insights into CCR2-mediated recruitment of blood monocyte subsets into damaged tissue, the dynamics and functional consequences of macrophage plasticity during the sequential...Continue Reading

References

Aug 6, 1999·Developmental Biology·L MiquerolA Nagy
Jan 6, 2000·Transgenic Research·B E ClausenI Förster
Jul 6, 2000·The American Journal of Pathology·J KishimotoR E Burgeson
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
Jun 18, 2003·The Journal of Cell Biology·Holger GerhardtChrister Betsholtz
Apr 15, 2004·Genesis : the Journal of Genetics and Development·Martin HafnerWerner Müller
Dec 3, 2005·Nature Reviews. Immunology·Siamon Gordon, Philip R Taylor
Feb 15, 2007·The Journal of Investigative Dermatology·Sabine A EmingJeffrey M Davidson
May 25, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Oscar OchoaPaula K Shireman
May 16, 2008·Nature·Geoffrey C GurtnerMichael T Longaker
Jul 18, 2008·Nature Reviews. Cancer·Craig MurdochClaire E Lewis
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Mar 14, 2009·Nature Reviews. Immunology·Jeffrey W Pollard
Feb 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tina LucasSabine A Eming
Apr 8, 2010·Cell·Bin-Zhi Qian, Jeffrey W Pollard
Aug 27, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hasina Hamilton OuttzJan Kitajewski
Oct 5, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Haiyan LuLan Zhou
Nov 26, 2010·The Journal of Investigative Dermatology·Christian StockmannRandall S Johnson
Dec 7, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jean K LimPhilip M Murphy
Jun 10, 2011·Nature·Bin-Zhi QianJeffrey W Pollard
Jun 15, 2011·Trends in Immunology·Molly A IngersollGwendalyn J Randolph

❮ Previous
Next ❯

Citations

Feb 2, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Mervin C Yoder
Aug 21, 2013·Journal of Dermatological Science·Nicholas S GreavesArdeshir Bayat
Jan 1, 2013·BoneKEy Reports·Andy C WuAllison R Pettit
Mar 4, 2014·Advances in Wound Care·Anca Sindrilaru, Karin Scharffetter-Kochanek
Apr 29, 2014·BioMed Research International·Pawel OlczykKatarzyna Komosinska-Vassev
Jun 8, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dagmara A SkoczekAnastasia Sobolewski
Apr 16, 2014·Stem Cell Research & Therapy·Amparo NavarroMaría Dolores Miñana
Mar 19, 2014·Immunology and Cell Biology·Jane E MooneyBarbara E Rolfe
Jul 16, 2014·Microvascular Research·Pollyana R CastroSilvia P Andrade
Oct 11, 2014·Advances in Wound Care·Kelly E Johnson, Traci A Wilgus
Sep 17, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Haytham ElgharablyChandan K Sen
Aug 26, 2014·Experimental Lung Research·Zulma X YuntWilliam J Janssen
Jun 5, 2014·Cell Communication & Adhesion·Gerardo Arrevillaga-BoniVianney Ortiz-Navarrete
Nov 27, 2015·The American Journal of Pathology·Deniz HosClaus Cursiefen
Sep 13, 2014·Journal of Cellular Physiology·Francisco J BlancoCarmelo Bernabeu
Nov 29, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Bruce A CorlissWalter Lee Murfee
Sep 2, 2015·Diabetes·Kate WicksKimberly A Mace
Jan 19, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mario Moisés AlvarezAli Khademhosseini
Dec 23, 2015·The Journal of Pathology·Ruoxi YuanLiwu Li
Nov 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Nader GhasemlouClifford J Woolf
Jun 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Francisco Ramírez-ValleJason G Cyster
Dec 8, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Scott A SeamanShayn M Peirce
Feb 14, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shin-ichiro OkizakiMasataka Majima
Oct 20, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Uwe FreudenbergCarsten Werner
Nov 3, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marko RoblekLubor Borsig
Sep 8, 2015·Experimental Neurology·David J Loane, Alok Kumar
Mar 18, 2016·Immunity·Thomas A Wynn, Kevin M Vannella
Nov 21, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christian E Jacome-GalarzaHector Leonardo Aguila
Sep 27, 2012·The Journal of Pathology·Alain BeschinJo A Van Ginderachter
Apr 24, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Haytham ElgharablyChandan K Sen
Jan 3, 2013·Experimental Dermatology·Mathieu P RoderoKiarash Khosrotehrani
Mar 4, 2014·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Sebastian Willenborg, Sabine A Eming
Aug 12, 2014·Journal of Cellular and Molecular Medicine·Anthal I P M SmitsFrank P T Baaijens
Jul 27, 2015·Cellular and Molecular Life Sciences : CMLS·Antonio SicaChiara Porta
Mar 30, 2016·Seminars in Immunology·Grégoire LauvauTobias M Hohl
Jul 23, 2015·Tissue Engineering. Part a·Hanna TalacuaFrank P T Baaijens
Apr 11, 2015·Cell·Chih-Chiang ChenCheng Ming Chuong
Apr 9, 2015·Clinical and Translational Medicine·Peter J Wermuth, Sergio A Jimenez
Jun 24, 2014·Seminars in Immunology·Kate WicksKimberly A Mace

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.