CCR2 Regulates the Immune Response by Modulating the Interconversion and Function of Effector and Regulatory T Cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
Eszter BakosIdit Shachar

Abstract

Chemokines and chemokine receptors establish a complex network modulating immune cell migration and localization. These molecules were also suggested to mediate the differentiation of leukocytes; however, their intrinsic, direct regulation of lymphocyte fate remained unclear. CCR2 is the main chemokine receptor inducing macrophage and monocyte recruitment to sites of inflammation, and it is also expressed on T cells. To assess whether CCR2 directly regulates T cell responses, we followed the fates of CCR2-/- T cells in T cell-specific inflammatory models. Our in vitro and in vivo results show that CCR2 intrinsically mediates the expression of inflammatory T cell cytokines, and its absence on T cells results in attenuated colitis progression. Moreover, CCR2 deficiency in T cells promoted a program inducing the accumulation of Foxp3+ regulatory T cells, while decreasing the levels of Th17 cells in vivo, indicating that CCR2 regulates the immune response by modulating the effector/regulatory T ratio.

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Citations

Nov 24, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Hedong ZhangWenhao Chen
Jun 16, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adolfo B FriasLouise M D'Cruz
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Mar 11, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jordi PedragosaAnna M Planas
Sep 6, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nathali KaushanskyAvraham Ben-Nun
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Apr 14, 2021·Journal of Experimental & Clinical Cancer Research : CR·Domenico MattoscioAntonio Recchiuti

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