Abstract
Chemokine receptors have been suggested to be preferentially expressed on CD4+ T cells with CCR3 and CCR8 linked to the T helper (Th) 2 subset and CCR5 and CXCR3 to the Th1 subset, however this remains controversial. Our aim was to compare the CCR3, CCR5, CCR8 and CXCR3 expression in memory Th cells from allergic, asymptomatically sensitized and healthy individuals. Peripheral blood mononuclear cells from 8 pollen allergic rhinitis patients, 10 asymptomatically sensitized and 10 healthy individuals were stimulated for 7 days with allergen or tetanus toxoid. CCR3, CCR5, CCR8, CXCR3, CD4 and CD45RO were detected by flow cytometry. No differences in chemokine receptor expression were observed between the three groups on day 0, and seven days of unstimulated culture did not change the expression. Both antigenic stimuli increased the chemokine receptor expression, tetanus toxoid being the most potent. No differences in percentage chemokine receptor positive memory Th cells were observed between the three groups on day 7. Only a change in MFI for CCR5 was significantly different between the three groups after allergen stimulation of the Th cells. We conclude that even though allergen and antigen induced increased chemokine receptor e...Continue Reading
References
Sep 26, 1997·Science·F SallustoA Lanzavecchia
Apr 4, 1998·The Journal of Experimental Medicine·F SallustoA Lanzavecchia
Mar 17, 1999·The Journal of Clinical Investigation·T L SørensenR M Ransohoff
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·K E BalashovW W Hancock
Feb 25, 2000·International Archives of Allergy and Immunology·P ParronchiE Maggi
Apr 13, 2000·European Journal of Immunology·A IellemD D'Ambrosio
Sep 21, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T PulleritsJ Lötvall
Dec 1, 2000·International Immunology·T Nanki, P E Lipsky
Jan 6, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·D D PatelL P Whichard
Jun 26, 2001·Human Immunology·J D CampbellK T HayGlass
Jul 6, 2001·Scandinavian Journal of Immunology·T AarvakJ B Natvig
Aug 2, 2001·Archives of Dermatological Research·Y HatanoS Takayasu
Aug 21, 2001·The Journal of Investigative Dermatology·M WakugawaK Tamaki
Nov 7, 2001·The Journal of Clinical Investigation·C H KimE C Butcher
Jul 12, 2002·Journal of Neurology·Natalia TeleshovaHans Link
Aug 23, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H OkazakiS Minota
Jan 18, 2003·The Journal of Allergy and Clinical Immunology·Uffe BodtgerHans-Jørgen Malling
Sep 12, 2003·Life Sciences·Helen GilchrestScott Greenfeder
Mar 9, 2004·Rheumatology International·Akiko UenoHirofumi Makino
Apr 20, 2004·Current Opinion in Allergy and Clinical Immunology·Uffe Bodtger
Oct 28, 2004·Molecular Nutrition & Food Research·Kirsten Skamstrup HansenHans-Jørgen Malling
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael GombertBernhard Homey
Feb 28, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K AssingL K Poulsen
Citations
Jul 8, 2008·Advances in Urology·M AlbersenH Van Poppel
Mar 3, 2009·Expert Review of Vaccines·Andre TanelRafick-Pierre Sékaly
Oct 13, 2017·European Journal of Medical Research·Ann-Britt LöfroosJan Marsal