CCR5 and CXCL12 allelic variants: Possible association with childhood neuroblastoma susceptibility?

Journal of Neuroimmunology
Daniel Rubens Marques Vieira-FilhoMaria Angelica Ehara Watanabe

Abstract

Neuroblastoma (NB) is a heterogeneous and particularly malignant childhood neoplasm in its higher stages, prone to form metastasis in selected organs and for which there is still no efficient treatment available beyond surgery. Evidence indicates that chemokines and their receptors present involvement as mediators of neuroinflammation and have a neurophysiological role. In the present study, we aimed to verify if CCR5 (rs333) and CXCL12 (rs1801157) allelic variants were associated with NB. For CCR5 (rs333) D32 carriers (OR: 5.96, IC: 2.21-16.06) and for CXCL12 genotype 3'A/3'A (OR:26.18, IC:6.15-111.4) there were statistically significant differences as well to allelic frequency (OR:4.20, IC: 2.19-8.03). Although no correlation was verified regarding prognostic parameters for both CCR5 and CXCL12 polymorphic variants, these polymorphisms may be associated with NB susceptibility which deserve attention for future investigations.

References

Oct 31, 1985·The New England Journal of Medicine·R C SeegerD Hammond
Apr 1, 1998·Journal of Neuroimmunology·L M BolinK B Bacon
Apr 2, 1999·Trends in Pharmacological Sciences·F MennickenR Quirion
Dec 19, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R C SeegerK K Matthay
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H GeminderA Ben-Baruch
Oct 16, 2001·The Journal of Biological Chemistry·M Chelli, M Alizon
Dec 4, 2003·Journal of Neuroimmunology·Laetitia CartierKarl-Heinz Krause
Apr 23, 2004·Trends in Immunology·Bernhard MoserPius Loetscher
Jul 2, 2004·Nature Reviews. Cancer·Fran Balkwill
Aug 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W B LondonS L Cohn
Dec 22, 2006·The Journal of Comparative Neurology·Phuong B TranRichard J Miller
Jan 12, 2007·Journal of Cutaneous Pathology·Karen Brajão de OliveiraMaria Angelica Ehara Watanabe
Jul 16, 2008·Journal of Clinical Laboratory Analysis·Sandra Marcia MuxelMaria Angelica Ehara Watanabe
Nov 19, 2008·Seminars in Cancer Biology·Nicole Gross, Roland Meier
May 14, 2014·Advances in Hematology·Carlos Eduardo Coral de OliveiraMaria Angelica Ehara Watanabe
Feb 27, 2015·Clinical and Experimental Medicine·Bruna Karina Banin-HirataMaria Angelica Ehara Watanabe
May 18, 2016·Journal of Translational Medicine·Daniela FormicolaMario Capasso
Nov 11, 2016·Molecular and Cellular Pediatrics·Patricia Midori Murobushi OzawaMaria Angelica Ehara Watanabe
Feb 9, 2018·F1000Research·Daniel F Legler, Marcus Thelen
Jan 14, 2020·Cancer Metastasis Reviews·Gian Paolo Tonini, Mario Capasso

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