PMID: 9450710Feb 5, 1998Paper

CCR5 chemokine receptor variant in HIV-1 mother-to-child transmission and disease progression in children. French Pediatric HIV Infection Study Group

JAMA : the Journal of the American Medical Association
M MisrahiS Blanche

Abstract

Studies suggest that adults with the CCR5delta32 deletion are less likely to become infected with the human immunodeficiency virus (HIV) and to develop HIV-related disease progression, but the effect of the mutation in children is not known. To study the effect of the CCR5 chemokine receptor mutant allele on mother-to-child transmission of HIV type 1 (HIV-1) and subsequent disease progression in infected children. Multicenter, prospective study of infants born to mothers seropositive for HIV-1. A total of 52 medical centers participating in the French Pediatric HIV Cohort studies. The CCR5delta32 deletion was studied in 512 non-African children, born between 1983 and 1996 to HIV-1-infected mothers. Among them, 276 children were infected and 236 were not. HIV-1 infection status and, in infected children followed up since birth, incidence of category B and C disease events and severe immunosuppression as defined in the new pediatric Centers for Disease Control and Prevention (CDC) classification, according to CCR5 genotype. The 32-base pair deleted allele was detected at a frequency of 0.05. Only 1 infant, not infected by HIV-1, was homozygous for the delta32 deletion. The 49 heterozygous children (9.6% of the total; 95% confiden...Continue Reading

Citations

Jan 11, 2013·Clinical & Developmental Immunology·Johanne PoudrierMichel Roger
Feb 12, 1999·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·A J BaileyM C Garcia-Rodriguez
Oct 13, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·A KimH Goldstein
Apr 13, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kumud K SinghStephen A Spector
Jul 27, 1999·Journal of Acquired Immune Deficiency Syndromes : JAIDS·S PhilpottB Weiser
Jan 7, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Despina G Contopoulos-IoannidisJohn P A Ioannidis
Aug 21, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·M MarmorUNKNOWN HIV Network for Prevention Trials Vaccine Preparedness Protocol Team
Mar 29, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·J M TaylorJ Margolick
Mar 9, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·A ManganoL Sen
Dec 7, 2011·Journal of Tropical Pediatrics·Joseph CavanaughKevin Cain
Jun 8, 1999·Annual Review of Immunology·E A BergerJ M Farber
Jun 6, 2003·Bioorganic & Medicinal Chemistry·Wieslaw KazmierskiTerry Kenakin
Aug 23, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Josiane WarszawskiStéphane Blanche
Nov 20, 2013·AIDS Research and Therapy·Gero HütterHarald Klüter
Jul 16, 2013·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·S BlancheUNKNOWN Cohorte française ANRS-EPF
Jan 6, 2016·AIDS·Christian R Aguilera-SandovalPaul Krogstad
Dec 16, 2010·International Journal of Immunogenetics·B Baron, P Schembri-Wismayer
Apr 5, 2005·The Journal of Allergy and Clinical Immunology·Mary E PaulUNKNOWN Women and Infants Transmission Study
Aug 17, 1999·Current Opinion in Immunology·N L Michael
Jan 17, 2002·Acta Microbiologica Et Immunologica Hungarica·C Casper, E M Fenyö
Nov 27, 1999·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Y LuR Yanagihara
Nov 24, 2004·FEMS Microbiology Letters·Eric de Silva, Michael P H Stumpf
Jan 4, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M Martínez-BonetM A Muñoz-Fernández
Apr 4, 2001·Memórias do Instituto Oswaldo Cruz·V Bongertz
Mar 4, 2000·Pediatric Clinics of North America·K Luzuriaga, J L Sullivan
Jul 20, 2001·AIDS Research and Human Retroviruses·F Salvatori, G Scarlatti
Feb 10, 2011·Journal of Translational Medicine·Mariangela Cavarelli, Gabriella Scarlatti
Dec 16, 2005·Cell Research·Tuo Fu ZhuBo Ping Zhou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.