CCR5 deficiency accelerates lipopolysaccharide-induced astrogliosis, amyloid-beta deposit and impaired memory function

Oncotarget
Chul Ju HwangJin Tae Hong

Abstract

Chemokine receptors are implicated in inflammation and immune responses. Neuro-inflammation is associated with activation of astrocyte and amyloid-beta (Aβ) generations that lead to pathogenesis of Alzheimer disease (AD). Previous our study showed that deficiency of CC chemokine receptor 5 (CCR5) results in activation of astrocytes and Aβ deposit, and thus memory dysfunction through increase of CC chemokine receptor 2 (CCR2) expression. CCR5 knockout mice were used as an animal model with memory dysfunction. For the purpose LPS was injected i.p. daily (0.25 mg/kg/day). The memory dysfunctions were much higher in LPS-injected CCR5 knockout mice compared to CCR5 wild type mice as well as non-injected CCR5 knockout mice. Associated with severe memory dysfuction in LPS injected CCR5 knockout mice, LPS injection significant increase expression of inflammatory proteins, astrocyte activation, expressions of β-secretase as well as Aβ deposition in the brain of CCR5 knockout mice as compared with that of CCR5 wild type mice. In CCR5 knockout mice, CCR2 expressions were high and co-localized with GFAP which was significantly elevated by LPS. Expression of monocyte chemoattractant protein-1 (MCP-1) which ligands of CCR2 also increased by ...Continue Reading

References

Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W S GriffinC Araoz
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J BusciglioB A Yankner
Apr 1, 1997·Journal of Neuropathology and Experimental Neurology·D W Dickson
Dec 23, 1998·Journal of Neuropathology and Experimental Neurology·S W Scheff, D A Price
Apr 6, 1999·Journal of Neurovirology·M Q Xia, B T Hyman
Nov 7, 2000·Journal of Neuroimmunology·M E DorfY Luo
Mar 29, 2001·Physiological Reviews·D J Selkoe
Apr 18, 2001·International Archives of Allergy and Immunology·A de PaulisP Romagnani
Jul 18, 2001·Frontiers in Neuroendocrinology·A BajettoG Schettini
May 16, 2002·Molecular Immunology·S Romagnani
Jun 18, 2002·Journal of Neurochemistry·G BanisadrS Mélik Parsadaniantz
Sep 25, 2002·Journal of Neuroscience Research·Anuska V AndjelkovicJoel S Pachter
Nov 29, 2002·Journal of Neural Transmission. Supplementum·T Arendt
Apr 1, 2003·Annals of Neurology·Daniela GalimbertiUNKNOWN Dutch-Italian Alzheimer Research Group
Apr 3, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kumar SambamurtiDebomoy K Lahiri
Jan 25, 2005·Journal of Neurochemistry·Steffen RossnerJ Regino Perez-Polo
Feb 4, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Svetlana M StamatovicAnuska V Andjelkovic
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Fletcher A WhiteRichard J Miller
Dec 2, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anna K StalderMathias Jucker
Jul 19, 2006·Molecular and Cellular Biology·Belete TeferedegneJeremy M Boss
Jun 17, 2008·European Journal of Pain : EJP·Michael A ThackerStephen B McMahon
Nov 5, 2008·The Journal of Clinical Investigation·Lawrence Steinman

❮ Previous
Next ❯

Citations

Aug 27, 2019·Frontiers in Aging Neuroscience·Tianwen Li, Jianhong Zhu
Feb 27, 2020·International Journal of Molecular Sciences·Anandi Rautenbach, Aurelia A Williams
Dec 28, 2018·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Joel Henrique EllwangerJosé Artur Bogo Chies

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
transgenic
light microscopy
fluorescence microscopy
electrophoresis

Software Mentioned

GraphPad Prism
GraphPad
Panlab
CS
SMART
LD

Related Concepts

Related Feeds

Astrocytes & Amyloid

Astrocytes are thought to play a role in amyloid production and have been implicated in neurodegenerative diseases such as Alzheimer’s disease. Here is the latest research on the relationship between astrocytes and amyloid.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.