CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury.

Cell
Mary T JoyS Thomas Carmichael

Abstract

We tested a newly described molecular memory system, CCR5 signaling, for its role in recovery after stroke and traumatic brain injury (TBI). CCR5 is uniquely expressed in cortical neurons after stroke. Post-stroke neuronal knockdown of CCR5 in pre-motor cortex leads to early recovery of motor control. Recovery is associated with preservation of dendritic spines, new patterns of cortical projections to contralateral pre-motor cortex, and upregulation of CREB and DLK signaling. Administration of a clinically utilized FDA-approved CCR5 antagonist, devised for HIV treatment, produces similar effects on motor recovery post stroke and cognitive decline post TBI. Finally, in a large clinical cohort of stroke patients, carriers for a naturally occurring loss-of-function mutation in CCR5 (CCR5-Δ32) exhibited greater recovery of neurological impairments and cognitive function. In summary, CCR5 is a translational target for neural repair in stroke and TBI and the first reported gene associated with enhanced recovery in human stroke.

Citations

May 28, 2019·BioTechniques·Jenny Straiton
Jul 10, 2019·Nature Immunology·Francesco Roselli, Markus Huber-Lang
Aug 21, 2019·Acta Neuropathologica Communications·Eric Y HaydenJason D Hinman
Oct 9, 2019·Stroke; a Journal of Cerebral Circulation·Hiroki AbeTakuya Takahashi
Aug 20, 2019·Current Topics in Medicinal Chemistry·Kenji MaedaHiroaki Takeuchi
Jan 7, 2020·Expert Opinion on Drug Metabolism & Toxicology·Miao MiaoGuangdi Li
Jan 14, 2020·Restorative Neurology and Neuroscience·Robert W RegenhardtDavid J Lin
Jan 10, 2020·Stem Cells and Development·Tianqi TuYong Jiang
Nov 20, 2019·Annual Review of Animal Biosciences·Stephen J O'Brien
May 21, 2020·Briefings in Functional Genomics·Jin-Yu SunXiao-Jie Lu
Jan 5, 2020·Cellular & Molecular Immunology·Dusanka S SkundricPaul C Montgomery
Aug 11, 2020·Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology·Jay N Pieczynski, Hooi Lynn Kee
Sep 22, 2020·Stroke; a Journal of Cerebral Circulation·Nick S Ward, S Thomas Carmichael
Sep 2, 2020·The Journal of Comparative Neurology·Maxime FougèreDimitri Ryczko
May 31, 2019·Current Neurology and Neuroscience Reports·Amit Kumar, Tomoko Kitago
Jan 25, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Julián N AcostaGuido J Falcone
Apr 1, 2020·Continuum : Lifelong Learning in Neurology·Steven C Cramer
Aug 8, 2020·The American Journal of Bioethics : AJOB·Bryan Cwik
Sep 19, 2019·Cambridge Quarterly of Healthcare Ethics : CQ : the International Journal of Healthcare Ethics Committees·Bryan Cwik
Jun 5, 2019·Nature Medicine·Xinzhu Wei, Rasmus Nielsen
Oct 9, 2019·Annual Review of Cell and Developmental Biology·Yishi Jin, Binhai Zheng
Nov 7, 2019·Human Reproduction·Benjamin Davies
Jun 13, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Andrés Felipe LealCarlos Javier Alméciga-Díaz
Jul 30, 2020·International Journal of Molecular Sciences·Saifudeen IsmaelTauheed Ishrat
Jun 30, 2019·Translational Stroke Research·Robert M DietzPaco S Herson
Jul 30, 2019·The Keio Journal of Medicine·Ryota SakaiMinako Ito
Jun 27, 2019·European Journal of Human Genetics : EJHG·Martin SandKarin R Jongsma
Aug 24, 2019·Frontiers in Cellular Neuroscience·Saef IzzyMichael J Whalen
Mar 15, 2019·Nature·Eric S LanderErnst-Ludwig Winnacker
Apr 3, 2019·Nature Reviews. Drug Discovery·M Teresa Villanueva
Mar 27, 2020·International Journal of Immunogenetics·Joel Henrique EllwangerJosé Artur Bogo Chies
May 8, 2020·Translational Stroke Research·Shirin Z BirjandiS Thomas Carmichael
Aug 27, 2019·Frontiers in Aging Neuroscience·Tianwen Li, Jianhong Zhu
Jul 31, 2020·Cerebral Cortex·Shahrzad LatifiS Thomas Carmichael
Feb 26, 2020·Current Pharmaceutical Design·Jun YangRuixia Zhu
Dec 23, 2020·Stroke; a Journal of Cerebral Circulation·Lorie G Richards, Steven C Cramer
Dec 31, 2020·Cell Reports Medicine·Christof KuglerGabor C Petzold
Jan 21, 2021·CNS Neuroscience & Therapeutics·Huan WangXiangjian Zhang

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