CCR7 deficiency exacerbates injury in acute nephritis due to aberrant localization of regulatory T cells.

Journal of the American Society of Nephrology : JASN
Kathrin EllerAntal Rot

Abstract

The homing of dendritic cells and T cells to secondary lymphoid organs requires chemokine receptor 7 (CCR7) expression on these cells. T cells mediate the pathogenesis of experimental accelerated nephrotoxic serum nephritis (NTS), including its suppression by regulatory T cells (Tregs), but the contribution of CCR7 to this disease is unknown. Here, we compared the development of NTS in CCR7-knockout (KO) and wild-type (WT) mice. Compared with WT mice, CCR7KO mice developed more severe disease with significantly more inflammatory cells infiltrating the kidney. These cells included FoxP3(+) Tregs, which were virtually absent from WT kidneys. The adoptive transfer of WT Tregs into CCR7KO mice at the time of immunization protected the recipients from disease; these cells homed to secondary lymphoid organs but not to kidneys. Conversely, adoptive transfer of CCR7KO Tregs into WT mice did not inhibit development of NTS. These data suggest that NTS can develop without CCR7 expression, but Treg-mediated disease suppression, which seems to occur in secondary lymphoid organs, requires CCR7.

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Citations

Apr 17, 2013·Cytokine & Growth Factor Reviews·Iain ComerfordShaun R McColl
Mar 20, 2010·Journal of the American Society of Nephrology : JASN·Jan-Eric TurnerUlf Panzer
Nov 10, 2012·Journal of the American Society of Nephrology : JASN·Jan-Hendrik RiedelUlf Panzer
Sep 14, 2010·Journal of Mammary Gland Biology and Neoplasia·Amanda W Lund, Melody A Swartz
Jan 19, 2016·Trends in Molecular Medicine·Thomas Ernandez, Tanya Norton Mayadas
May 2, 2013·The Journal of Allergy and Clinical Immunology·Roshi AfsharAndrew D Luster
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Oct 22, 2014·Nature Reviews. Nephrology·Hye Ryoun Jang, Hamid Rabb
May 14, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Katharina ArtingerKathrin Eller
Jun 7, 2016·Kidney International·Min HuStephen I Alexander
Nov 5, 2015·Journal of the American Society of Nephrology : JASN·Hans-Joachim PaustUlf Panzer
Sep 8, 2017·American Journal of Physiology. Renal Physiology·Rahul Sharma, Gilbert R Kinsey
Jul 11, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Young-In KimSun-Young Chang
Oct 18, 2018·American Journal of Physiology. Renal Physiology·Ida AringerKathrin Eller
Jan 17, 2019·American Journal of Physiology. Renal Physiology·Stefanie KlingeHans-Willi Mittrücker
Nov 10, 2012·Journal of the American Society of Nephrology : JASN·Kathrin Eller, Alexander R Rosenkranz
May 4, 2013·Journal of the American Society of Nephrology : JASN·Annett OstmannGisa Tiegs
Dec 5, 2009·Journal of the American Society of Nephrology : JASN·Oliver M SteinmetzUlf Panzer
Jun 6, 2018·Journal of the American Society of Nephrology : JASN·Paul DiefenhardtOliver M Steinmetz
Apr 9, 2011·Journal of the American Society of Nephrology : JASN·Arthur C K Chung, Hui Y Lan
Dec 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathrin EllerAnna M Wolf
Jun 15, 2012·American Journal of Physiology. Renal Physiology·A H KirschK Eller
Dec 15, 2020·Cell and Tissue Research·G R Herrnstadt, O M Steinmetz
Feb 19, 2021·Cell and Tissue Research·Jan-Hendrik RiedelUlf Panzer

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